MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas

Anja Roehle, Kai P. Hoefig, Dirk Repsilber, Christoph Thorns, Marita Ziepert, Kai O. Wesche, Marlen Thiere, Markus Loeffler, Wolfram Klapper, Michael Pfreundschuh, A. Matolcsy, Heinz Wolfram Bernd, Lila Reiniger, Hartmut Merz, Alfred C. Feller

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

MicroRNAs (miRNA, miR) are negative regulators of gene expression that play an important role in diverse biological processes such as development, cell growth, apoptosis and haematopoiesis, suggesting their association with cancer. Here we analysed the expression signatures of 157 miRNAs in 58 diffuse large B-cell lymphoma (DLBCL), 46 follicular lymphoma (FL) and seven non-neoplastic lymph nodes (LN). Comparison of the possible combinations of DLBCL-, FL- and LN resulted in specific DLBCL- and FL-signatures, which include miRNAs with previously published function in haematopoiesis (MIRN150 and MIRN155) or tumour development (MIRN210, MIRN10A, MIRN17-5P and MIRN145). As compared to LN, some miRNAs are differentially regulated in both lymphoma types (MIRN155, MIRN210, MIRN106A, MIRN149 and MIRN139). Conversely, some miRNAs show lymphoma-specific aberrant expression, such as MIRN9/9*, MIRN301, MIRN338 and MIRN213 in FL and MIRN150, MIRN17-5P, MIRN145, MIRN328 and others in DLBCL. A classification tree was computed using four miRNAs (MIRN330, MIRN17-5P, MIRN106a and MIRN210) to correctly identify 98% of all 111 cases that were analysed in this study. Finally, eight miRNAs were found to correlate with event-free and overall survival in DLBCL including known tumour suppressors (MIRN21, MIRN127 and MIRN34a) and oncogenes (MIRN195 and MIRNLET7G).

Original languageEnglish
Pages (from-to)732-744
Number of pages13
JournalBritish Journal of Haematology
Volume142
Issue number5
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
MicroRNAs
Lymph Nodes
Hematopoiesis
Lymphoma
Biological Phenomena
Neoplasms
Regulator Genes
Growth and Development
Oncogenes
Disease-Free Survival
Apoptosis
Gene Expression

Keywords

  • Diffuse large B-cell lymphoma
  • Follicular lymphoma
  • Lymphoma
  • MicroRNA

ASJC Scopus subject areas

  • Hematology

Cite this

Roehle, A., Hoefig, K. P., Repsilber, D., Thorns, C., Ziepert, M., Wesche, K. O., ... Feller, A. C. (2008). MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. British Journal of Haematology, 142(5), 732-744. https://doi.org/10.1111/j.1365-2141.2008.07237.x

MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. / Roehle, Anja; Hoefig, Kai P.; Repsilber, Dirk; Thorns, Christoph; Ziepert, Marita; Wesche, Kai O.; Thiere, Marlen; Loeffler, Markus; Klapper, Wolfram; Pfreundschuh, Michael; Matolcsy, A.; Bernd, Heinz Wolfram; Reiniger, Lila; Merz, Hartmut; Feller, Alfred C.

In: British Journal of Haematology, Vol. 142, No. 5, 09.2008, p. 732-744.

Research output: Contribution to journalArticle

Roehle, A, Hoefig, KP, Repsilber, D, Thorns, C, Ziepert, M, Wesche, KO, Thiere, M, Loeffler, M, Klapper, W, Pfreundschuh, M, Matolcsy, A, Bernd, HW, Reiniger, L, Merz, H & Feller, AC 2008, 'MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas', British Journal of Haematology, vol. 142, no. 5, pp. 732-744. https://doi.org/10.1111/j.1365-2141.2008.07237.x
Roehle, Anja ; Hoefig, Kai P. ; Repsilber, Dirk ; Thorns, Christoph ; Ziepert, Marita ; Wesche, Kai O. ; Thiere, Marlen ; Loeffler, Markus ; Klapper, Wolfram ; Pfreundschuh, Michael ; Matolcsy, A. ; Bernd, Heinz Wolfram ; Reiniger, Lila ; Merz, Hartmut ; Feller, Alfred C. / MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. In: British Journal of Haematology. 2008 ; Vol. 142, No. 5. pp. 732-744.
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AU - Wesche, Kai O.

AU - Thiere, Marlen

AU - Loeffler, Markus

AU - Klapper, Wolfram

AU - Pfreundschuh, Michael

AU - Matolcsy, A.

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