Mikro-RNS-ek és szerepük hematológiai malignus betegségekben.

Translated title of the contribution: [MicroRNA-s and their role in malignant hematologic diseases].

Zsuzsanna Gaál, E. Oláh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

MicroRNAs are a class of small non-coding RNAs regulating gene expression at posttranscriptional level. Their target genes include numerous regulators of cell cycle, cell proliferation as well as apoptosis. Therefore, they are implicated in the initiation and progression of cancer, tissue invasion and metastasis formation as well. MicroRNA profiles supply much information about both the origin and the differentiation state of tumours. MicroRNAs also have a key role during haemopoiesis. An altered expression level of those have often been observed in different types of leukemia. There are successful attempts to apply microRNAs in the diagnosis and prognosis of acute lymphoblastic leukemia and acute myeloid leukemia. Measurement of the expression levels may help to predict the success of treatment with different kinds of chemotherapeutic drugs. MicroRNAs are also regarded as promising therapeutic targets, and can contribute to a more personalized therapeutic approach in haemato-oncologic patients.

Original languageHungarian
Pages (from-to)2051-2059
Number of pages9
JournalOrvosi Hetilap
Volume153
Issue number52
Publication statusPublished - Dec 30 2012

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Hematologic Diseases
MicroRNAs
Small Untranslated RNA
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Neoplasms
Cell Cycle
Leukemia
Therapeutics
Cell Proliferation
Apoptosis
Neoplasm Metastasis
Gene Expression
Pharmaceutical Preparations
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mikro-RNS-ek és szerepük hematológiai malignus betegségekben. / Gaál, Zsuzsanna; Oláh, E.

In: Orvosi Hetilap, Vol. 153, No. 52, 30.12.2012, p. 2051-2059.

Research output: Contribution to journalArticle

Gaál, Zsuzsanna ; Oláh, E. / Mikro-RNS-ek és szerepük hematológiai malignus betegségekben. In: Orvosi Hetilap. 2012 ; Vol. 153, No. 52. pp. 2051-2059.
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