Microreactor assisted method for studying isocyanate–alcohol reaction kinetics

Christian Orlando Camacho López, Zsolt Fejes, B. Viskolcz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Kinetic parameters of phenyl isocyanate–monoalcohol reactions has been studied using a microreactor system. The monoalcohol components were propan-1-ol, butan-1-ol, propan-2-ol and butan-2-ol. The reactions were conducted in alcohol/THF mixed solvent under pseudo-first-order circumstances at various temperatures. The reaction mixtures were analyzed by off-line HPLC. Reaction rate constants and apparent activation energies have been determined with good precision. The reaction rate constants were higher for the primary alcohols than for the secondary alcohols. Higher apparent activation energy was found for the secondary alcohols compared to the primary ones. The applied technique provides a simple way to study the effects of various factors (e.g. structure of the isocyanate and the alcohol, temperature, solvents, concentration of reagents, catalysis) on the kinetics of the isocyanate–alcohol reactions.

Original languageEnglish
JournalJournal of Flow Chemistry
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Reaction kinetics
Alcohols
Reaction rates
Rate constants
Activation energy
Isocyanates
Kinetic parameters
Catalysis
Temperature
Kinetics

Keywords

  • Flow chemistry
  • Isocyanate
  • Kinetics
  • Microreactor
  • Urethane formation

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Fluid Flow and Transfer Processes
  • Organic Chemistry

Cite this

Microreactor assisted method for studying isocyanate–alcohol reaction kinetics. / López, Christian Orlando Camacho; Fejes, Zsolt; Viskolcz, B.

In: Journal of Flow Chemistry, 01.01.2019.

Research output: Contribution to journalArticle

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