Microparticles, microspheres, and microcapsules for advanced drug delivery

Miléna Lengyel, Nikolett Kállai-Szabó, Vince Antal, András József Laki, István Antal

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1-1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.

Original languageEnglish
Article number20
JournalScientia Pharmaceutica
Volume87
Issue number3
DOIs
Publication statusPublished - Sep 2019

Fingerprint

Drug Delivery Systems
Microspheres
Capsules
Excipients
Pharmaceutical Preparations
Microbubbles
Microfluidics
Freeze Drying
Patient Compliance
Pharmacokinetics
Insulin
Therapeutics

Keywords

  • Microbubbles
  • Microfluidics
  • Microsponge
  • Multiparticulate formulations
  • Polymer excipients
  • Processes for microparticles in therapy
  • Structure and drug release

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Microparticles, microspheres, and microcapsules for advanced drug delivery. / Lengyel, Miléna; Kállai-Szabó, Nikolett; Antal, Vince; Laki, András József; Antal, István.

In: Scientia Pharmaceutica, Vol. 87, No. 3, 20, 09.2019.

Research output: Contribution to journalReview article

Lengyel, Miléna ; Kállai-Szabó, Nikolett ; Antal, Vince ; Laki, András József ; Antal, István. / Microparticles, microspheres, and microcapsules for advanced drug delivery. In: Scientia Pharmaceutica. 2019 ; Vol. 87, No. 3.
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