Microglia and the Purinergic Signaling System

Stefano Calovi, Paula Mut-Arbona, B. Sperlágh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Microglia are the main resident immune-competent cell type of the central nervous system (CNS); these cells are highly sensitive to subtle changes in the chemical environment of the brain. Microglia are activated during diverse conditions, such as apoptosis, trauma, inflammation, and infection. The specific activities of microglia result from the confluence of environmental stimuli and the cellular state. It is likely that several signaling systems with different biological functions operate in competition and/or synergy, thus regulating similar microglial behaviors. The purinergic system is one of the fundamental signaling systems that establish microglial behavior in a wide spectrum of conditions. Adenosine tri-phosphate (ATP) belongs to the purinergic signaling system, which includes P2X, P2Y, and P1 receptors, as well as other proteins participating in ATP secretion and extracellular ATP degradation, and molecules that recognize purines as a ligand. In this review, we focus on the latest pre-clinical and basic purinergic system and microglial research, with particular attention to data collected in vivo and ex vivo. This chapter is divided into sections related to microglial ATP release, ATP degradation, and ATP-related actions mediated by P2X and P2Y receptor activation.

Original languageEnglish
JournalNeuroscience
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Adenine Nucleotides
Microglia
Purines
Central Nervous System
Apoptosis
Ligands
Inflammation
Wounds and Injuries
Brain
Infection
Research
Proteins

Keywords

  • adenosine tri-phosphate (ATP)
  • central nervous system
  • microglia
  • neuro-immunology
  • purinergic signaling system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Microglia and the Purinergic Signaling System. / Calovi, Stefano; Mut-Arbona, Paula; Sperlágh, B.

In: Neuroscience, 01.01.2019.

Research output: Contribution to journalArticle

Calovi, Stefano ; Mut-Arbona, Paula ; Sperlágh, B. / Microglia and the Purinergic Signaling System. In: Neuroscience. 2019.
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