Microfluidically Integrated SERS Active Cell Trap Array for Sensitive Analysis of Red Blood Cells

Orsolya Hakkel, Istvan Rigo, Miklos Veres, Peter Furjes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Surface enhanced Raman scattering (SERS) spectra of normal blood sample were recorded and analysed by using a periodic SERS active structure integrated in microfluidic injection system. Vertically perforated membranes were fabricated by 3D micromachining and applied for subsequent sample preparation (filtration / cell entrapment) and Raman Spectroscopy. The optical behavior of the 3D structure was characterized by FDTD simulation. SERS spectra of blood plasma and trapped red blood cells (RBCs) were recorded and compared to verify the functionality of the bioanalytical microsystem. The main molecular components of RBCs (membrane lipids, hemoglobin, etc.) could be detected separately from the plasma.

Original languageEnglish
Title of host publication2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages964-967
Number of pages4
ISBN (Electronic)9781728120072
DOIs
Publication statusPublished - Jun 2019
Event20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII - Berlin, Germany
Duration: Jun 23 2019Jun 27 2019

Publication series

Name2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII

Conference

Conference20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
CountryGermany
CityBerlin
Period6/23/196/27/19

Keywords

  • 3D micromachining
  • Surface Enhanced Raman Spectroscopy - SERS
  • blood
  • cell trapping
  • microfluidics
  • molecular analysis
  • periodic micro- and nanostructures

ASJC Scopus subject areas

  • Process Chemistry and Technology
  • Spectroscopy
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Electronic, Optical and Magnetic Materials
  • Control and Optimization
  • Instrumentation

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  • Cite this

    Hakkel, O., Rigo, I., Veres, M., & Furjes, P. (2019). Microfluidically Integrated SERS Active Cell Trap Array for Sensitive Analysis of Red Blood Cells. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII (pp. 964-967). [8808438] (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2019.8808438