Microfluidic "thin chips" for chemical separations

Attila Gaspar, Marisol Salgado, Schetema Stevens, Frank A. Gomez

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This paper describes the design, development and application of microfluidic "thin chips"; fabricated from PDMS. Thin chips consist of multiple layers of PDMS chemically bonded onto each other. Unlike thicker PDMS chips that suffer from lack of sensitivity due to PDMS absorption in the VIS and UV range, the thinness of these chips allows for the detection of chromophoric species within the microchannel via an external fiber optics detection system. C18-modified reversed-phase silica particles are packed into the microchannel using a temporary taper created by a magnetic valve and separations using both pressure- and electrochromatographic-driven methods are detailed.

Original languageEnglish
Pages (from-to)2520-2525
Number of pages6
JournalELECTROPHORESIS
Volume31
Issue number15
DOIs
Publication statusPublished - Aug 1 2010

Keywords

  • Electrochromatography
  • Microfluidic thin chips
  • PDMS
  • Reversed-phase silica particles

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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