Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017

Alexander Nagy, A. Dán, Lenka Černíková, Eliška Vitásková, Vlastimil Křivda, Jitka Horníčková, Roman Masopust, Kamil Sedlák

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Abstract

Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalArchives of Virology
DOIs
Publication statusAccepted/In press - Apr 5 2018

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Influenza in Birds
Czech Republic
Disease Outbreaks
Orthomyxoviridae
avian influenza A virus hemagglutinin
H5N8 Subtype Influenza A Virus

ASJC Scopus subject areas

  • Virology

Cite this

Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017. / Nagy, Alexander; Dán, A.; Černíková, Lenka; Vitásková, Eliška; Křivda, Vlastimil; Horníčková, Jitka; Masopust, Roman; Sedlák, Kamil.

In: Archives of Virology, 05.04.2018, p. 1-6.

Research output: Contribution to journalArticle

Nagy, Alexander ; Dán, A. ; Černíková, Lenka ; Vitásková, Eliška ; Křivda, Vlastimil ; Horníčková, Jitka ; Masopust, Roman ; Sedlák, Kamil. / Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017. In: Archives of Virology. 2018 ; pp. 1-6.
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