Gyogyszervegyuletek mikroegyensulyai

Translated title of the contribution: Microequilibria of drug molecules

B. Noszál, Károly Mazák, Zoltán Szakács

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Protonation macro-, micro-, and submicro constants are physico-chemical parameters of crucial importance, concerning the fate of bio-, drug, and narcotic drug molecules in the body and in protic solvents. The most important characteristics, relationships, applications and biological significance of these parameters are reviewed, using acetylcysteine and cysteine, as examples. The mucolytic effect of acetylcysteine, an active principle in numerous drugs, is interpreted in terms of protonation state of the molecule and its thiolate site. Microscopic protonation constants of acetylcysteine, data that have not previously appeared, are also reported.

Original languageHungarian
Pages (from-to)108-114
Number of pages7
JournalActa Pharmaceutica Hungarica
Volume69
Issue number3
Publication statusPublished - Jun 1999

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Acetylcysteine
Pharmaceutical Preparations
Expectorants
Narcotics
Cysteine

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Noszál, B., Mazák, K., & Szakács, Z. (1999). Gyogyszervegyuletek mikroegyensulyai. Acta Pharmaceutica Hungarica, 69(3), 108-114.

Gyogyszervegyuletek mikroegyensulyai. / Noszál, B.; Mazák, Károly; Szakács, Zoltán.

In: Acta Pharmaceutica Hungarica, Vol. 69, No. 3, 06.1999, p. 108-114.

Research output: Contribution to journalArticle

Noszál, B, Mazák, K & Szakács, Z 1999, 'Gyogyszervegyuletek mikroegyensulyai', Acta Pharmaceutica Hungarica, vol. 69, no. 3, pp. 108-114.
Noszál B, Mazák K, Szakács Z. Gyogyszervegyuletek mikroegyensulyai. Acta Pharmaceutica Hungarica. 1999 Jun;69(3):108-114.
Noszál, B. ; Mazák, Károly ; Szakács, Zoltán. / Gyogyszervegyuletek mikroegyensulyai. In: Acta Pharmaceutica Hungarica. 1999 ; Vol. 69, No. 3. pp. 108-114.
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