Microelectrophysiological analysis of the cardiac effect of prostaglandin E2

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Abstract

PGE2 produced a dose dependent dual effect on the maximal rate of depolarization V(max) and overshoot (OS) of the transmembrane potential of the cat and guinea pig auricles and the rat ventricle. Low concentration (5 ng/ml) of PGE2 caused a marked increase of V(max) in all species, while OS was slightly increased (in the cat and the rat) or remained unchanged (in the guinea pig). These changes were not related to changes in resting potential. PGE2 in higher concentration (20 ng/ml) evoked an opposite effect: V(max) was strongly depressed in all preparations and a variable degree of depression of OS (decrease in the auricles and no change in the ventricle) was also observed. PGE2, 20 ng/ml, strongly decreased the resting potential. The repolarization phase was prolongs affected in the various species but in this respect the biphasic effect was absent.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalPolish Journal of Pharmacology and Pharmacy
Volume26
Issue number1-2
Publication statusPublished - 1974

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Dinoprostone
Membrane Potentials
Guinea Pigs
Cats

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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Microelectrophysiological analysis of the cardiac effect of prostaglandin E2. / Kecskeméti, V.; Kelemen, K.; Knoll, J.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 26, No. 1-2, 1974, p. 171-176.

Research output: Contribution to journalArticle

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