A mikroflóra és a bélnyálkahártya kölcsönhatása az irritábilis bél, irritábilis szem és irritábilis elme szindróma kórtanában és kezelésében

Translated title of the contribution: Microbiota-host symbiosis in the pathophysiology and treatment of irritable bowel, irritable eye and irritable mind syndrome

János Fehér, Illés Kovács, Elena Pacella, Zsolt Radák

Research output: Contribution to journalArticle

4 Citations (Scopus)


Accumulating clinical evidence supports co-morbidity of irritable bowel, irritable eye and irritable mind symptoms. Furthermore, perturbation of the microbiota-host symbiosis (dysbiosis) is considered a common pathogenic mechanism connecting gastrointestinal, ocular and neuropsychiatric symptoms. Consequently, maintaining or restoring microbiota-host symbiosis represents a new approach to treat these symptoms or to prevent their relapses. Current treatment approach assigned a primary role to live probiotics alone or in combination with prebiotics to enhance colonization of beneficial bacteria and to strengthen the symbiosis. However, several papers showed major benefits of heat-killed probiotics as compared to their live counterparts on both intestinal and systemic symptoms. Recently, in addition to killing probiotics, in a proof of concept study lysates (fragments) of probiotics in combination with vitamins A, B, D and omega 3 fatty acids were successfully tested. These findings suggested a conceptual change in the approach addressed to both the microbiota and host as targets for intervention. Orv. Hetil., 2014, 155(37), 1454-1460.

Original languageHungarian
Pages (from-to)1454-1460
Number of pages7
JournalOrvosi hetilap
Issue number37
Publication statusPublished - Sep 1 2014


ASJC Scopus subject areas

  • Medicine(all)

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