Microbiological and clinical aspects of cervicofacial Actinomyces infections: An overview

Márió Gajdács, Edit Urbán, Gabriella Terhes

Research output: Contribution to journalReview article

7 Citations (Scopus)


Similarly to other non-spore-forming Gram-positive anaerobes, members of the Actinomyces genus are important saprophytic constituents of the normal microbiota of humans. Actinomyces infections are considered to be rare, with cervicofacial infections (also known as ‘lumpy jaw syndrome’) being the most prevalent type in the clinical practice. Actinomycoses are characterized by a slowly progressing (indolent) infection, with non-specific symptoms, and additionally, the clinical presentation of the signs/symptoms can mimic other pathologies, such as solid tumors, active Mycobacterium tuberculosis infections, nocardiosis, fungal infections, infarctions, and so on. The clinical diagnosis of actinomycosis may be difficult due to its non-specific symptoms and the fastidious, slow-growing nature of the pathogens, requiring an anaerobic atmosphere for primary isolation. Based on 111 references, the aim of this review is to summarize current advances regarding the clinical features, diagnostics, and therapy of cervicofacial Actinomyces infections and act as a paper for dentistry specialists, other physicians, and clinical microbiologists.

Original languageEnglish
Article number85
JournalDentistry Journal
Issue number3
Publication statusPublished - Sep 1 2019


  • Actinomyces
  • Actinomycosis
  • Cervicofacial infection

ASJC Scopus subject areas

  • Dentistry(all)

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