Mice lacking histidine decarboxylase exhibit abnormal mast cells

Hiroshi Ohtsu, Satoshi Tanaka, Tadashi Terui, Yoshio Hori, Yoko Makabe-Kobayashi, Gunnar Pejler, Elena Tchougounova, Lars Hellman, Marina Gertsenstein, Noriyasu Hirasawa, Eiko Sakurai, Edit Buzás, Péter Kovács, György Csaba, Ágnes Kittel, Mikiko Okada, Masahiro Hara, Lynn Mar, Keiko Numayama-Tsuruta, Satsuki Ishigaki-SuzukiKazuo Ohuchi, Atsushi Ichikawa, András Falus, Takehiko Watanabe, András Nagy

Research output: Contribution to journalArticle

317 Citations (Scopus)

Abstract

Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalFEBS letters
Volume502
Issue number1-2
DOIs
Publication statusPublished - Jul 27 2001

Keywords

  • Histamine
  • Knockout
  • Mast cell
  • Rodent

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Ohtsu, H., Tanaka, S., Terui, T., Hori, Y., Makabe-Kobayashi, Y., Pejler, G., Tchougounova, E., Hellman, L., Gertsenstein, M., Hirasawa, N., Sakurai, E., Buzás, E., Kovács, P., Csaba, G., Kittel, Á., Okada, M., Hara, M., Mar, L., Numayama-Tsuruta, K., ... Nagy, A. (2001). Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS letters, 502(1-2), 53-56. https://doi.org/10.1016/S0014-5793(01)02663-1