MFIB: A repository of protein complexes with mutual folding induced by binding

Erzsébet Fichó, István Reményi, I. Simon, Bálint Mészáros

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Motivation It is commonplace that intrinsically disordered proteins (IDPs) are involved in crucial interactions in the living cell. However, the study of protein complexes formed exclusively by IDPs is hindered by the lack of data and such analyses remain sporadic. Systematic studies benefited other types of protein-protein interactions paving a way from basic science to therapeutics; yet these efforts require reliable datasets that are currently lacking for synergistically folding complexes of IDPs. Results Here we present the Mutual Folding Induced by Binding (MFIB) database, the first systematic collection of complexes formed exclusively by IDPs. MFIB contains an order of magnitude more data than any dataset used in corresponding studies and offers a wide coverage of known IDP complexes in terms of flexibility, oligomeric composition and protein function from all domains of life. The included complexes are grouped using a hierarchical classification and are complemented with structural and functional annotations. MFIB is backed by a firm development team and infrastructure, and together with possible future community collaboration it will provide the cornerstone for structural and functional studies of IDP complexes. Availability and implementation MFIB is freely accessible at http://mfib.enzim.ttk.mta.hu/. The MFIB application is hosted by Apache web server and was implemented in PHP. To enrich querying features and to enhance backend performance a MySQL database was also created. Contact simon.istvan@ttk.mta.hu, meszaros.balint@ttk.mta.hu Supplementary informationSupplementary dataare available at Bioinformatics online.

Original languageEnglish
Pages (from-to)3682-3684
Number of pages3
JournalBioinformatics
Volume33
Issue number22
DOIs
Publication statusPublished - Nov 15 2017

Fingerprint

Intrinsically Disordered Proteins
Folding
Repository
Proteins
Protein
Databases
Bioinformatics
Computational Biology
Hierarchical Classification
Web Server
Protein-protein Interaction
Servers
Cells
Availability
Annotation
Coverage
Infrastructure
Flexibility
Contact
Chemical analysis

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

Cite this

MFIB : A repository of protein complexes with mutual folding induced by binding. / Fichó, Erzsébet; Reményi, István; Simon, I.; Mészáros, Bálint.

In: Bioinformatics, Vol. 33, No. 22, 15.11.2017, p. 3682-3684.

Research output: Contribution to journalArticle

Fichó, Erzsébet ; Reményi, István ; Simon, I. ; Mészáros, Bálint. / MFIB : A repository of protein complexes with mutual folding induced by binding. In: Bioinformatics. 2017 ; Vol. 33, No. 22. pp. 3682-3684.
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