Metoprolol reduces reperfusion-induced fibrillation in he isolated rat heart

Protection is secondary to bradycardia

A. Tósaki, Laszlo Szekeres, David J. Hearse

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We studied the effect of metoprolol on the incidence of reperfusion-induced ventricular fibrillation in the isolated rat heart with transient coronary artery occlusion and reperfusion. When administered prior to ischemia, metoprolol produced a dose-dependent reduction in reperfusion-induced ventricular fibrillation. Thus, with 1, 10, 30, 50, 100, and 200 μmol/L metoprolol, total ventricular fibrillation (reversible plus irreversible) was reduced from its control incidence of 100% to 91%, 83%, 58% (p <0.05), 25% (p <0.001), 25% (p <0.001), and 0% (p <0.001), respectively. Heart rate was also reduced in a dose-dependent manner from its control value of 268 ± 6 beats/min to

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Volume10
Issue number5
Publication statusPublished - 1987

Fingerprint

Metoprolol
Ventricular Fibrillation
Bradycardia
Reperfusion
Myocardial Reperfusion
Coronary Occlusion
Incidence
Coronary Vessels
Ischemia
Heart Rate

Keywords

  • Arrhythmias
  • Ischemia
  • Metoprolol
  • Rat heart
  • Reperfusion
  • β-blockers

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Metoprolol reduces reperfusion-induced fibrillation in he isolated rat heart : Protection is secondary to bradycardia. / Tósaki, A.; Szekeres, Laszlo; Hearse, David J.

In: Journal of Cardiovascular Pharmacology, Vol. 10, No. 5, 1987, p. 489-497.

Research output: Contribution to journalArticle

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