Metolose-PEG interaction as seen by positron annihilation spectroscopy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The plasticizing effects of poly(ethylene glycol) (PEG 400) on methylcellulose (Metolose) cast films were studied by conventional physicochemical methods and positron annihilation spectroscopy. The PEG concentrations relative to the total polymer content were varied within the range 0-75% (w/w). At low concentrations (below 33.3%, w/w), the plasticizer was found to build in into the methylcellulose structure. On the other hand, at higher concentrations (above 50%, w/w), it formed small separate phases in the films. Positron annihilation spectroscopy (PALS) was applied to track the Metolose-PEG interaction. Controlled ageing of Metolose-PEG films at room temperature and at 75% RH revealed a significant difference between the ageing processes of the monophase and those of the separate phase films. The ageing involves two steps in both cases: a fast and a slow one. The PALS measurements demonstrated that the slow process is hindered in the phase-separated samples.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume313
Issue number1-2
DOIs
Publication statusPublished - Apr 26 2006

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Spectrum Analysis
Methylcellulose
Electrons
Plasticizers
Ethylene Glycol
Polymers
Temperature
polyethylene glycol 400

Keywords

  • Deformation process
  • Positron annihilation spectroscopy
  • Thermal behaviour

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Metolose-PEG interaction as seen by positron annihilation spectroscopy. / Pintye-Hódi, K.; Regdon, G.; Eros, I.; Süvegh, K.; Marek, T.; Kéry, I.; Zelkó, R.

In: International Journal of Pharmaceutics, Vol. 313, No. 1-2, 26.04.2006, p. 66-71.

Research output: Contribution to journalArticle

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abstract = "The plasticizing effects of poly(ethylene glycol) (PEG 400) on methylcellulose (Metolose) cast films were studied by conventional physicochemical methods and positron annihilation spectroscopy. The PEG concentrations relative to the total polymer content were varied within the range 0-75{\%} (w/w). At low concentrations (below 33.3{\%}, w/w), the plasticizer was found to build in into the methylcellulose structure. On the other hand, at higher concentrations (above 50{\%}, w/w), it formed small separate phases in the films. Positron annihilation spectroscopy (PALS) was applied to track the Metolose-PEG interaction. Controlled ageing of Metolose-PEG films at room temperature and at 75{\%} RH revealed a significant difference between the ageing processes of the monophase and those of the separate phase films. The ageing involves two steps in both cases: a fast and a slow one. The PALS measurements demonstrated that the slow process is hindered in the phase-separated samples.",
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AU - Regdon, G.

AU - Eros, I.

AU - Süvegh, K.

AU - Marek, T.

AU - Kéry, I.

AU - Zelkó, R.

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