Methylxanthines and inflammatory cells

György Haskó, Bruce Cronstein

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

Both caffeine and theophylline have a variety of roles in regulating inflammatory responses. At pharmacologically relevant concentrations most of the effects of these commonly used methylxanthines are attributable to adenosine receptor blockade and histone deacetylase activation. In addition, at higher concentrations methylxanthines can suppress inflammation by inhibiting phosphodiesterases, thereby elevating intracellular cyclic adenosine monophosphate levels. In summary, methylxanthines regulate inflammation by multiple mechanisms.

Original languageEnglish
Title of host publicationMethylxanthines
EditorsBertil Fredholm
Pages457-468
Number of pages12
DOIs
Publication statusPublished - Jan 1 2011

Publication series

NameHandbook of Experimental Pharmacology
Volume200
ISSN (Print)0171-2004

Keywords

  • Arthritis
  • Asthma
  • Chronic obstructive pulmonary disease
  • Cytokine
  • Macrophage
  • Methothrexate
  • Monocyte
  • Neutrophil
  • Protein kinase A
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Haskó, G., & Cronstein, B. (2011). Methylxanthines and inflammatory cells. In B. Fredholm (Ed.), Methylxanthines (pp. 457-468). (Handbook of Experimental Pharmacology; Vol. 200). https://doi.org/10.1007/978-3-642-13443-2_18