Methods to study thermonociception in rodents

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The study of thermonociception in conscious animals is based on the assessment of pain-avoiding behavior from noxious heat or cold stimuli. The conventional tests of heat nociception apply suprathreshold heat stimuli and measure the reflex latency of withdrawal reactions. A novel approach of heat sensitivity measurement is the application of slowly increasing heat stimulation to determine the noxious heat threshold which proved to be highly reproducible and sensitive to standard analgesics. The present chapter aims at providing a guide to the most widely used conventional thermonociceptive tests (constant-temperature hot plate, plantar test, tail-flick test), as well as an introduction to the novel methods, the increasing-temperature hot plate and water bath. In a third section, the methods to test noxious cold sensitivity are briefly described.

Original languageEnglish
Title of host publicationMethods in Pharmacology and Toxicology
Pages401-417
Number of pages17
DOIs
Publication statusPublished - 2012

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)15572153
ISSN (Electronic)19406053

Fingerprint

Rodentia
Hot Temperature
Pain Measurement
Baths
Reflex
Analgesics
Tail
Water

Keywords

  • Cold plate
  • Hot plate
  • Increasing-temperature hot plate
  • Increasing-temperature water bath
  • Noxious heat threshold
  • Plantar test
  • Reflex latency
  • Tail-flick
  • Thermonociception

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Molecular Medicine
  • Pharmacology (medical)

Cite this

Bölcskei, K. (2012). Methods to study thermonociception in rodents. In Methods in Pharmacology and Toxicology (pp. 401-417). (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-62703-095-3_25

Methods to study thermonociception in rodents. / Bölcskei, K.

Methods in Pharmacology and Toxicology. 2012. p. 401-417 (Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bölcskei, K 2012, Methods to study thermonociception in rodents. in Methods in Pharmacology and Toxicology. Methods in Pharmacology and Toxicology, pp. 401-417. https://doi.org/10.1007/978-1-62703-095-3_25
Bölcskei K. Methods to study thermonociception in rodents. In Methods in Pharmacology and Toxicology. 2012. p. 401-417. (Methods in Pharmacology and Toxicology). https://doi.org/10.1007/978-1-62703-095-3_25
Bölcskei, K. / Methods to study thermonociception in rodents. Methods in Pharmacology and Toxicology. 2012. pp. 401-417 (Methods in Pharmacology and Toxicology).
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