Methods of investigation for cardiac autonomic dysfunction in human research studies

Luciano Bernardi, Vincenza Spallone, Martin Stevens, Jannik Hilsted, Simona Frontoni, Rodica Pop-Busui, Dan Ziegler, P. Kempler, Roy Freeman, Phillip Low, Solomon Tesfaye, Paul Valensi

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

This consensus document provides evidence-based guidelines regarding the evaluation of diabetic cardiovascular autonomic neuropathy (CAN) for human research studies; the guidelines are the result of the work of the CAN Subcommittee of the Toronto Diabetic Neuropathy Expert Group. The subcommittee critically reviewed the limitations and strengths of the available diagnostic approaches for CAN and the need for developing new tests for autonomic function. It was concluded that the most sensitive and specific approaches currently available to evaluate CAN in clinical research are: (1) heart rate variability, (2) baroreflex sensitivity, (3) muscle sympathetic nerve activity, (4) plasma catecholamines, and (5) heart sympathetic imaging. It was also recommended that efforts should be undertaken to develop new non-invasive and safe CAN tests to be used in clinical research, with higher sensitivity and specificity, for studying the pathophysiology of CAN and evaluating new therapeutic approaches.

Original languageEnglish
Pages (from-to)654-664
Number of pages11
JournalDiabetes/Metabolism Research and Reviews
Volume27
Issue number7
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Diabetic Neuropathies
Research
Guidelines
Baroreflex
Catecholamines
Heart Rate
Sensitivity and Specificity
Muscles
Therapeutics

Keywords

  • Baroreflex sensitivity
  • Cardiac imaging
  • Catecholamines
  • Diabetic neuropathy
  • Heart rate variability
  • Microneurography

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Medicine(all)

Cite this

Bernardi, L., Spallone, V., Stevens, M., Hilsted, J., Frontoni, S., Pop-Busui, R., ... Valensi, P. (2011). Methods of investigation for cardiac autonomic dysfunction in human research studies. Diabetes/Metabolism Research and Reviews, 27(7), 654-664. https://doi.org/10.1002/dmrr.1224

Methods of investigation for cardiac autonomic dysfunction in human research studies. / Bernardi, Luciano; Spallone, Vincenza; Stevens, Martin; Hilsted, Jannik; Frontoni, Simona; Pop-Busui, Rodica; Ziegler, Dan; Kempler, P.; Freeman, Roy; Low, Phillip; Tesfaye, Solomon; Valensi, Paul.

In: Diabetes/Metabolism Research and Reviews, Vol. 27, No. 7, 10.2011, p. 654-664.

Research output: Contribution to journalArticle

Bernardi, L, Spallone, V, Stevens, M, Hilsted, J, Frontoni, S, Pop-Busui, R, Ziegler, D, Kempler, P, Freeman, R, Low, P, Tesfaye, S & Valensi, P 2011, 'Methods of investigation for cardiac autonomic dysfunction in human research studies', Diabetes/Metabolism Research and Reviews, vol. 27, no. 7, pp. 654-664. https://doi.org/10.1002/dmrr.1224
Bernardi L, Spallone V, Stevens M, Hilsted J, Frontoni S, Pop-Busui R et al. Methods of investigation for cardiac autonomic dysfunction in human research studies. Diabetes/Metabolism Research and Reviews. 2011 Oct;27(7):654-664. https://doi.org/10.1002/dmrr.1224
Bernardi, Luciano ; Spallone, Vincenza ; Stevens, Martin ; Hilsted, Jannik ; Frontoni, Simona ; Pop-Busui, Rodica ; Ziegler, Dan ; Kempler, P. ; Freeman, Roy ; Low, Phillip ; Tesfaye, Solomon ; Valensi, Paul. / Methods of investigation for cardiac autonomic dysfunction in human research studies. In: Diabetes/Metabolism Research and Reviews. 2011 ; Vol. 27, No. 7. pp. 654-664.
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