Method development for the high-performance liquid chromatographic enantioseparation of 2-cyanocycloalkanols

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An indirect high-performance liquid chromatographic method is developed for the enantioseparation of cis- and trans-2-cyanocyclopentanol and -cyclohexanol. The racemic cis-(1S,2S and 1R,2R)- or trans-(1S,2R and 1R,2S)-2-cyanocycloalkanols are converted to their diastereomers formed with (S)-(+)- or (R)-(-)-α-methoxy-α-(trifluoromethyl)phenylacetyl chloride. The diastereomers are separated on a reversed-phase column, and the conditions of derivatization and HPLC analysis are optimized.

Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalJournal of chromatographic science
Issue number5
Publication statusPublished - May 2001


ASJC Scopus subject areas

  • Analytical Chemistry

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