Methionine enkephalin and morphine alter monoamine and cyclic nucleotide levels in the cerebral ganglia of the freshwater bivalve Anodonta cygnea

George B. Stefano, Laszlo Hiripi

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40 Citations (Scopus)


Methionine enkephalin and morphine increased dopamine levels in the cerebral ganglia of Anodonta cygnea. Both agents increased the levels of C'GMP and depressed the levels of C'AMP. The pharmacological effect on dopamine and cyclic nucleotide levels were blocked by prior treatments of the cerebral ganglia with naloxone. The study demonstrates pharmacologically the possible existence of an opiate receptor mechanism.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalLife Sciences
Issue number3
Publication statusPublished - Jul 16 1979


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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