A [ 11c]-metionin pozitron emissziós tomográfia alkalmazása korai prosztatarák diagnosztikájában

Translated title of the contribution: Methionin positron emission tomography in the early diagnosis of prostatic cancer

Tóth György, Z. Lengyel, L. Balkay, M. Salah, L. Trón, Tóth Csaba

Research output: Contribution to journalArticle

Abstract

Detection of primary prostate cancer with positron emission tomography (PET) using 11C-labeled methionine (MET) in patients with elevated prostate specific antigen (PSA) level and repeatedly negative biopsies. 20 consecutive patients with elevated serum PSA level and negative repeated biopsies were included in the study. Their age ranged from 52 to 75 (average 65). PSA levels measured have ranged from 3.49 ng/ml to 28.6 ng/ml (average 936 ng/ml). Dynamic PET-images were obtained from the prostate region using 11C-labeled MET. Suspicious accumulations (SA) of the tracer were anatomically localized using MR-images and were used as guidance during the next biopsy. PET was positive in 15 (75%) patients, in 7 of whom (46.7%) the next repeated biopsy verified carcinoma. The overall detection rate was 35% (7/20) and 46.7% (7/15) in the whole group and in the PET-positive group, respectively. 5/5 patients with negative MET PET had negative biopsies. MET-PET of the prostate with short dynamic scanning and with multicore biopsies is a useful method to ensure high detection rate of prostate cancer in patients with elevated PSA and repeated negative biopsies.

Original languageHungarian
Pages (from-to)79-86
Number of pages8
JournalMagyar Urologia
Volume17
Issue number2
Publication statusPublished - 2005

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Early Detection of Cancer
Positron-Emission Tomography
Prostatic Neoplasms
Biopsy
Prostate-Specific Antigen
Methionine
Prostate
Carcinoma
Serum

ASJC Scopus subject areas

  • Urology

Cite this

A [ 11c]-metionin pozitron emissziós tomográfia alkalmazása korai prosztatarák diagnosztikájában. / György, Tóth; Lengyel, Z.; Balkay, L.; Salah, M.; Trón, L.; Csaba, Tóth.

In: Magyar Urologia, Vol. 17, No. 2, 2005, p. 79-86.

Research output: Contribution to journalArticle

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abstract = "Detection of primary prostate cancer with positron emission tomography (PET) using 11C-labeled methionine (MET) in patients with elevated prostate specific antigen (PSA) level and repeatedly negative biopsies. 20 consecutive patients with elevated serum PSA level and negative repeated biopsies were included in the study. Their age ranged from 52 to 75 (average 65). PSA levels measured have ranged from 3.49 ng/ml to 28.6 ng/ml (average 936 ng/ml). Dynamic PET-images were obtained from the prostate region using 11C-labeled MET. Suspicious accumulations (SA) of the tracer were anatomically localized using MR-images and were used as guidance during the next biopsy. PET was positive in 15 (75{\%}) patients, in 7 of whom (46.7{\%}) the next repeated biopsy verified carcinoma. The overall detection rate was 35{\%} (7/20) and 46.7{\%} (7/15) in the whole group and in the PET-positive group, respectively. 5/5 patients with negative MET PET had negative biopsies. MET-PET of the prostate with short dynamic scanning and with multicore biopsies is a useful method to ensure high detection rate of prostate cancer in patients with elevated PSA and repeated negative biopsies.",
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