Methamphetamine in high dose has been reported to induce stereotypic behavior of abnormal form in the pigeon and domestic chick. A number of reports suggested that the target of methamphetamine was the paleostriatal complex, the highest motor center of the avian brain. The present study tested this hypothesis by treating newly-hatched domestic chicks with high dose of methamphetamine (10 mg/kg b.w.) after complete decerebration or sham operation. Stereotypic mandibulations were observed both in sham-operated and in decerebrated birds in similar form following methamphetamine treatment. The results suggested that brainstem pattern generators remain responsive to dopaminergic stimuli in the absence of the main telencephalic (striatal) targets.
- Basal ganglia
- Domestic chick
- Stereotypic behavior
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience