Metformin induces significant reduction of body weight, total cholesterol and LDL levels in the elderly – A meta-analysis

Margit Solymár, Ivan Ivic, László Pótó, Péter Hegyi, András Garami, Petra Hartmann, Erika Pétervári, László Czopf, Alizadeh Hussain, Zoltán Gyöngyi, Patrícia Sarlós, Mária Simon, Péter Mátrai, Bálint Bérczi, Márta Balaskó

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Abstract

Background Metformin is the first-choice drug for patients with Type 2 diabetes, and this therapy is characterized by being weight neutral. However, in the elderly an additional unintentional weight loss could be considered as an adverse effect of the treatment. Objectives We aimed to perform a meta-analysis of placebo-controlled studies investigating the body weight changes upon metformin treatment in participants older than 60 years. Materials and methods PubMed, EMBASE and the Cochrane Library were searched. We included at least 12 week-long studies with placebo control where the mean age of the metformin-treated patients was 60 years or older and the body weight changes of the patients were reported. We registered our protocol on PROSPERO (CRD42017055287). Results From the 971 articles identified by the search, 6 randomized placebo-controlled studies (RCTs) were included in the meta-analysis (n = 1541 participants). A raw difference of -2.23 kg (95% CI: -2.84 –-1.62 kg) body weight change was detected in the metformin-treated groups as compared with that of the placebo groups (p<0.001). Both total cholesterol (-0.184 mmol/L, p<0.001) and LDL cholesterol levels (-0.182 mmol/L, p<0.001) decreased upon metformin-treatment. Conclusions Our meta-analysis of RCTs showed a small reduction of body weight together with slight improvement of the blood lipid profile in patients over 60 years. With regard to the risk of unintentional weight loss, metformin seems to be a safe agent in the population of over 60 years. Our results also suggest that metformin treatment may reduce the risk of major coronary events (-4-5%) and all-cause mortality (-2%) in elderly diabetic populations.

Original languageEnglish
Article numbere0207947
JournalPloS one
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2018

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Solymár, M., Ivic, I., Pótó, L., Hegyi, P., Garami, A., Hartmann, P., Pétervári, E., Czopf, L., Hussain, A., Gyöngyi, Z., Sarlós, P., Simon, M., Mátrai, P., Bérczi, B., & Balaskó, M. (2018). Metformin induces significant reduction of body weight, total cholesterol and LDL levels in the elderly – A meta-analysis. PloS one, 13(11), [e0207947]. https://doi.org/10.1371/journal.pone.0207947