Metastatic Spread from Abdominal Tumor Cells to Parathymic Lymph Nodes

Gábor Király, Zoltán Hargitai, I. Kovács, Gábor Szemán-Nagy, I. Juhász, G. Bánfalvi

Research output: Contribution to journalArticle

Abstract

Metastatic studies on rats showed that after subrenal implantation of tumor cells under the capsule of the kidney or subhepatic implantation under Glisson’s capsule of the liver generated primary tumors in these organs. It was assumed that tumor cells that escaped through the disrupted peripheral blood vessels of primary tumors entered the peritoneal cavity, crossed the diaphragm, and appeared in the thoracal, primarily in the parathymic lymph nodes. This explanation did not answer the question whether distant lymph nodes were reached via the blood stream from the primary tumor or through the thoracal lymphatic vessels. In this work, we investigated the metastatic pathway in C3H/HeJ mice, after direct intraperitoneal administration of murine SCC VII cells bypassing the hematogenic spread of tumor cells. The direct pathway was also mimicked by intraperitoneal injection of Pelican Ink colloidal particles, which appeared in the parathymic lymph nodes, similarly to the tumor cells that caused metastasis in the parathymic lymph nodes and in the thymic tissue. The murine peritoneal-parathymic lymph node route indicates a general mechanism of tumor progression from the abdominal effusion. This pathway starts with the growth of abdominal tumors, continues as thoracal metastasis in parathymic lymph nodes and may proceed as mammary lymph node metastasis.

Original languageEnglish
JournalPathology and Oncology Research
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Lymph Nodes
Neoplasms
Neoplasm Metastasis
Capsules
Vascular Tissue Neoplasms
Ink
Lymphatic Vessels
Inbred C3H Mouse
Peritoneal Cavity
Diaphragm
Intraperitoneal Injections
Breast
Kidney
Liver
Growth

Keywords

  • Carcinoma cell line
  • Colloidal ink
  • Murine metastasis model
  • Parathymic lymph node

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Cite this

Metastatic Spread from Abdominal Tumor Cells to Parathymic Lymph Nodes. / Király, Gábor; Hargitai, Zoltán; Kovács, I.; Szemán-Nagy, Gábor; Juhász, I.; Bánfalvi, G.

In: Pathology and Oncology Research, 01.01.2018.

Research output: Contribution to journalArticle

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