Metastasizing rat nephroblastoma. A rodent Wilms' tumour model

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In newborn F344 rats, immunosuppressed with antithymocyte sera and xenografted with various human tumours (lymphomas and melanomas), regular development of nephroblastomas was observed. Transplantation experiments and chromosome analysis proved the rat origin of the tumours. The histological appearance of these rat nephroblastomas closely resemble that of the human Wilms' tumour, in which three basic components: blastema, stroma and immature epithelium can be distinguished. With serial subcutaneous, lung-subcutaneous transplantations in immunocompetent newborn animals a spontaneously metastatic line to the lung was selected. In adult hosts, lung metastasis occurred only following orthotopic (subrenal capsule) implantation. The histogenesis and the morphological features of this rat nephroblastoma and its metastases are described.

Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalCarcinogenesis
Volume15
Issue number6
Publication statusPublished - Jun 1994

Fingerprint

Wilms Tumor
Rats
Tumors
Tumor
Rodentia
Lung
Transplantation
Metastasis
Neoplasm Metastasis
Newborn Animals
Melanoma
Implantation
Lung Transplantation
Inbred F344 Rats
Chromosomes
Model
Chromosome
Capsules
Animals
Lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience

Cite this

Metastasizing rat nephroblastoma. A rodent Wilms' tumour model. / Rásó, E.; Tímár, J.; Paku, S.; Lapis, K.

In: Carcinogenesis, Vol. 15, No. 6, 06.1994, p. 1243-1249.

Research output: Contribution to journalArticle

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