Metal ion-induced permeability changes in cell membranes: A minireview

Tibor Kiss, Oleg Osipenko

Research output: Contribution to journalArticle

23 Citations (Scopus)


1. The paper summarizes the effects of the metal ions Cu2+, Pb2+, Ag+, Hg2+, Zn2+, and Cd2+ applied externally or internally to the surface membrane of different excitable cells. 2. Conductance changes induced by metal ions, and metal ion-activated current, are compared with respect to their ion and voltage dependence. 3. It is suggested that metal ion-induced effects can be realized through special structures of the cell membrane, the metal ion "receptors," although other mechanisms, as, for example, competition for Ca-binding sites in the channel forming proteins, cannot be excluded.

Original languageEnglish
Pages (from-to)781-789
Number of pages9
JournalCellular and Molecular Neurobiology
Issue number6
Publication statusPublished - Dec 1 1994



  • excitable membrane
  • heavy metal
  • ionic channel
  • metal ion-induced current

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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