Metal deposition and functional neurotoxicity in rats after 3-6 weeks nasal exposure by two physicochemical forms of manganese

Gábor Oszlánczi, Tünde Vezér, Leila Sárközi, Edina Horváth, Andrea Szabó, Endre Horváth, Zoltán Kónya, András Papp

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Airborne manganese represents a major risk of nervous system damage first of all in industrial settings. The resulting effects may depend on the dose and physicochemical form of Mn. To compare the effect of soluble and nanoparticulate Mn, adult male rats received daily instillation of MnCl2 solution or MnO2 nanoparticle suspension (dose: 2.53mg Mn per rat) into the nasal cavity for 3 and 6 weeks. At the end of treatment, spontaneous open field motility was tested, electrophysiological recording was done in anesthesia, and brain tissue Mn level was determined. Metal level increase in the rats' brain, body weight gain reduction, and decrease of open field motility was significant in the MnCl2, but not nano-Mn, treated rats. Most evoked cortical activity parameters were significantly altered in both groups, but spontaneous cortical activity spectrum only in the rats receiving MnCl2. There was fair correlation between brain Mn levels and certain neuro-functional parameters, underlining the causal relationship. Electrophysiological tests might be more sensitive to the effects of Mn than general toxicological or neurobehavioral tests.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalEnvironmental Toxicology and Pharmacology
Volume30
Issue number2
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Manganese
Nose
Rats
Metals
Brain
Nasal Cavity
Neurology
Nanoparticles
Toxicology
Nervous System
Weight Gain
Weight Loss
Suspensions
Anesthesia
Body Weight
Tissue
manganese chloride

Keywords

  • Electrocorticogram
  • Evoked potentials
  • Intranasal application
  • Manganese
  • Nanoparticles
  • Neurotoxicity
  • Open field
  • Rat

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Pharmacology

Cite this

Metal deposition and functional neurotoxicity in rats after 3-6 weeks nasal exposure by two physicochemical forms of manganese. / Oszlánczi, Gábor; Vezér, Tünde; Sárközi, Leila; Horváth, Edina; Szabó, Andrea; Horváth, Endre; Kónya, Zoltán; Papp, András.

In: Environmental Toxicology and Pharmacology, Vol. 30, No. 2, 09.2010, p. 121-126.

Research output: Contribution to journalArticle

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