Abstract
Potentiometry and spectrophotometry were used to study the cobalt(II) complexes of L-cysteine, D-penicillamine, DL-mercaptosuccinic acid, N-acetyl-L-cysteine, N-acetyl-D-penicillamine, α-mercaptopropionylglycine and glutathione. It was found that L-cysteine and D-penicillamine form octahedral bis complexes of composition CoA2 with the cobalt(II) ion. At intermediate pH values polynuclear complexes too are formed; this is the case primarily for L-cysteine. Pentacoordinated complexes CoA2 are produced with mercaptosuccinic acid, and the concentration of the polynuclear species is negligible. N-acetyl-D-penicillamine forms a distorted tetrahedral bis complex by (S,O) coordination. Besides an analogous species, polynuclear and mixed hydroxo complexes too may be present in the cobalt(II)N-acetyl-L-cysteine system. In a weakly basic medium the cobalt(II) ion does not induce deprotonation of the peptide NH group for either mercaptopropionylglycine or glutathione. In the case of mercaptopropionylglycine the formation of the parent complexes is accompanied by their hydrolysis, while for glutathione there is the possibility of both cysteine-type and glutamic acid side-chain coordination.
| Original language | English |
|---|---|
| Pages (from-to) | 75-83 |
| Number of pages | 9 |
| Journal | Inorganica Chimica Acta |
| Volume | 80 |
| Issue number | C |
| DOIs | |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
- Physical and Theoretical Chemistry
- Materials Chemistry
Cite this
Metal complexes of sulphur-containinng ligands. V. Interactions of cobalt(II) ion with L-cysteine and its derivatives. / Harman, Béla; Sóvágó, I.
In: Inorganica Chimica Acta, Vol. 80, No. C, 1983, p. 75-83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metal complexes of sulphur-containinng ligands. V. Interactions of cobalt(II) ion with L-cysteine and its derivatives
AU - Harman, Béla
AU - Sóvágó, I.
PY - 1983
Y1 - 1983
N2 - Potentiometry and spectrophotometry were used to study the cobalt(II) complexes of L-cysteine, D-penicillamine, DL-mercaptosuccinic acid, N-acetyl-L-cysteine, N-acetyl-D-penicillamine, α-mercaptopropionylglycine and glutathione. It was found that L-cysteine and D-penicillamine form octahedral bis complexes of composition CoA2 with the cobalt(II) ion. At intermediate pH values polynuclear complexes too are formed; this is the case primarily for L-cysteine. Pentacoordinated complexes CoA2 are produced with mercaptosuccinic acid, and the concentration of the polynuclear species is negligible. N-acetyl-D-penicillamine forms a distorted tetrahedral bis complex by (S,O) coordination. Besides an analogous species, polynuclear and mixed hydroxo complexes too may be present in the cobalt(II)N-acetyl-L-cysteine system. In a weakly basic medium the cobalt(II) ion does not induce deprotonation of the peptide NH group for either mercaptopropionylglycine or glutathione. In the case of mercaptopropionylglycine the formation of the parent complexes is accompanied by their hydrolysis, while for glutathione there is the possibility of both cysteine-type and glutamic acid side-chain coordination.
AB - Potentiometry and spectrophotometry were used to study the cobalt(II) complexes of L-cysteine, D-penicillamine, DL-mercaptosuccinic acid, N-acetyl-L-cysteine, N-acetyl-D-penicillamine, α-mercaptopropionylglycine and glutathione. It was found that L-cysteine and D-penicillamine form octahedral bis complexes of composition CoA2 with the cobalt(II) ion. At intermediate pH values polynuclear complexes too are formed; this is the case primarily for L-cysteine. Pentacoordinated complexes CoA2 are produced with mercaptosuccinic acid, and the concentration of the polynuclear species is negligible. N-acetyl-D-penicillamine forms a distorted tetrahedral bis complex by (S,O) coordination. Besides an analogous species, polynuclear and mixed hydroxo complexes too may be present in the cobalt(II)N-acetyl-L-cysteine system. In a weakly basic medium the cobalt(II) ion does not induce deprotonation of the peptide NH group for either mercaptopropionylglycine or glutathione. In the case of mercaptopropionylglycine the formation of the parent complexes is accompanied by their hydrolysis, while for glutathione there is the possibility of both cysteine-type and glutamic acid side-chain coordination.
UR - http://www.scopus.com/inward/record.url?scp=0001996878&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0001996878&partnerID=8YFLogxK
U2 - 10.1016/S0020-1693(00)91264-7
DO - 10.1016/S0020-1693(00)91264-7
M3 - Article
AN - SCOPUS:0001996878
VL - 80
SP - 75
EP - 83
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
SN - 0020-1693
IS - C
ER -