Metal complexes of sulphur-containinng ligands. V. Interactions of cobalt(II) ion with L-cysteine and its derivatives

Béla Harman, I. Sóvágó

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Abstract

Potentiometry and spectrophotometry were used to study the cobalt(II) complexes of L-cysteine, D-penicillamine, DL-mercaptosuccinic acid, N-acetyl-L-cysteine, N-acetyl-D-penicillamine, α-mercaptopropionylglycine and glutathione. It was found that L-cysteine and D-penicillamine form octahedral bis complexes of composition CoA2 with the cobalt(II) ion. At intermediate pH values polynuclear complexes too are formed; this is the case primarily for L-cysteine. Pentacoordinated complexes CoA2 are produced with mercaptosuccinic acid, and the concentration of the polynuclear species is negligible. N-acetyl-D-penicillamine forms a distorted tetrahedral bis complex by (S,O) coordination. Besides an analogous species, polynuclear and mixed hydroxo complexes too may be present in the cobalt(II)N-acetyl-L-cysteine system. In a weakly basic medium the cobalt(II) ion does not induce deprotonation of the peptide NH group for either mercaptopropionylglycine or glutathione. In the case of mercaptopropionylglycine the formation of the parent complexes is accompanied by their hydrolysis, while for glutathione there is the possibility of both cysteine-type and glutamic acid side-chain coordination.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalInorganica Chimica Acta
Volume80
Issue numberC
DOIs
Publication statusPublished - 1983

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Penicillamine
Coordination Complexes
cysteine
Tiopronin
Metal complexes
Cobalt
Sulfur
Cysteine
sulfur
cobalt
Ligands
Ions
Derivatives
Glutathione
ligands
glutathione
Acetylcysteine
metals
Acids
ions

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Metal complexes of sulphur-containinng ligands. V. Interactions of cobalt(II) ion with L-cysteine and its derivatives. / Harman, Béla; Sóvágó, I.

In: Inorganica Chimica Acta, Vol. 80, No. C, 1983, p. 75-83.

Research output: Contribution to journalArticle

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