Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]Cl · H2Sha, a model for a peroxidase-inhibitor complex

Eimear C. O'Brien, E. Farkas, Marie Jose Gil, Desmond Fitzgerald, Alfonso Castineras, Kevin B. Nolan

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 °C, I = 0.2 mol dm-3 KCl in aqueous solution. The complex stability order, iron(III) >> copper(II) > nickel(II) ~ zinc(II) was observed whilst complexes of H2Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metal ion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)2(Cl)]Cl · H2Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalJournal of Inorganic Biochemistry
Volume79
Issue number1-4
DOIs
Publication statusPublished - Apr 30 2000

Fingerprint

Phenanthrolines
Coordination Complexes
Molecular Structure
Nickel
Molecular structure
Peroxidase
Zinc
Copper
Iron
Crystal structure
Ligands
Metal ions
Ions
Crystalline materials
anthranilic hydroxamic acid
salicylhydroxamic acid
benzohydroxamic acid
1,10-phenanthroline

Keywords

  • Enzyme-inhibitor complex
  • Hydroxamic acids
  • Metal complexes
  • PK(a) values
  • Stability constants

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]Cl · H2Sha, a model for a peroxidase-inhibitor complex. / O'Brien, Eimear C.; Farkas, E.; Gil, Marie Jose; Fitzgerald, Desmond; Castineras, Alfonso; Nolan, Kevin B.

In: Journal of Inorganic Biochemistry, Vol. 79, No. 1-4, 30.04.2000, p. 47-51.

Research output: Contribution to journalArticle

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AU - O'Brien, Eimear C.

AU - Farkas, E.

AU - Gil, Marie Jose

AU - Fitzgerald, Desmond

AU - Castineras, Alfonso

AU - Nolan, Kevin B.

PY - 2000/4/30

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N2 - Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 °C, I = 0.2 mol dm-3 KCl in aqueous solution. The complex stability order, iron(III) >> copper(II) > nickel(II) ~ zinc(II) was observed whilst complexes of H2Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metal ion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)2(Cl)]Cl · H2Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions. (C) 2000 Elsevier Science Inc.

AB - Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 °C, I = 0.2 mol dm-3 KCl in aqueous solution. The complex stability order, iron(III) >> copper(II) > nickel(II) ~ zinc(II) was observed whilst complexes of H2Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metal ion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)2(Cl)]Cl · H2Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions. (C) 2000 Elsevier Science Inc.

KW - Enzyme-inhibitor complex

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