Abstract
Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 °C, I = 0.2 mol dm-3 KCl in aqueous solution. The complex stability order, iron(III) >> copper(II) > nickel(II) ~ zinc(II) was observed whilst complexes of H2Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metal ion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)2(Cl)]Cl · H2Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions. (C) 2000 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 47-51 |
| Number of pages | 5 |
| Journal | Journal of Inorganic Biochemistry |
| Volume | 79 |
| Issue number | 1-4 |
| DOIs | |
| Publication status | Published - Apr 30 2000 |
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Keywords
- Enzyme-inhibitor complex
- Hydroxamic acids
- Metal complexes
- PK(a) values
- Stability constants
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
Cite this
Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]Cl · H2Sha, a model for a peroxidase-inhibitor complex. / O'Brien, Eimear C.; Farkas, E.; Gil, Marie Jose; Fitzgerald, Desmond; Castineras, Alfonso; Nolan, Kevin B.
In: Journal of Inorganic Biochemistry, Vol. 79, No. 1-4, 30.04.2000, p. 47-51.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]Cl · H2Sha, a model for a peroxidase-inhibitor complex
AU - O'Brien, Eimear C.
AU - Farkas, E.
AU - Gil, Marie Jose
AU - Fitzgerald, Desmond
AU - Castineras, Alfonso
AU - Nolan, Kevin B.
PY - 2000/4/30
Y1 - 2000/4/30
N2 - Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 °C, I = 0.2 mol dm-3 KCl in aqueous solution. The complex stability order, iron(III) >> copper(II) > nickel(II) ~ zinc(II) was observed whilst complexes of H2Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metal ion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)2(Cl)]Cl · H2Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions. (C) 2000 Elsevier Science Inc.
AB - Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 °C, I = 0.2 mol dm-3 KCl in aqueous solution. The complex stability order, iron(III) >> copper(II) > nickel(II) ~ zinc(II) was observed whilst complexes of H2Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metal ion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)2(Cl)]Cl · H2Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions. (C) 2000 Elsevier Science Inc.
KW - Enzyme-inhibitor complex
KW - Hydroxamic acids
KW - Metal complexes
KW - PK(a) values
KW - Stability constants
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UR - http://www.scopus.com/inward/citedby.url?scp=0034732648&partnerID=8YFLogxK
U2 - 10.1016/S0162-0134(99)00245-7
DO - 10.1016/S0162-0134(99)00245-7
M3 - Article
VL - 79
SP - 47
EP - 51
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
IS - 1-4
ER -