Metal binding ability of hypermodified nucleosides of t-RNA. Potentiometric and spectroscopic studies on the metal complexes of N-[(9-β-D-ribofuranosylpurin-6-yl)carbamoyl] threonine

Malgorzata Jezowska-Bojczuk, Henryk Kozlowski, K. Várnagy, I. Sóvágó, Jolanta Swiatek, Ryszard W. Adamiak

Research output: Contribution to journalArticle

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Abstract

Copper(II), nickel(II), zinc(II), manganese(II), and magnesium(II) complexes of t6A (N-[9-β-D-ribofuranosylpurin-6-yl)carbamoyl] threonine and t6Ade (N6(threoninocarbonyl)adenine) were studied by potentiometric and spectroscopic methods. It was found that t6Ade has three dissociable protons in the accessible pH range (N1 and N9 of purine and carboxylate), while only two pK values are characteristic of t6A. Magnesium(II) and manganese(II) do not interact effectively with these ligands, but copper(II) and nickel(II) ions form very stable complexes with the coordination of purine N1, deprotonated amide nitrogen, and carboxy late oxygen donors.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalJournal of Inorganic Biochemistry
Volume40
Issue number4
DOIs
Publication statusPublished - 1990

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Coordination Complexes
Threonine
Manganese
Nickel
Nucleosides
Magnesium
Copper
Metals
RNA
Adenine
Amides
Protons
Zinc
Nitrogen
Ions
Oxygen
Ligands
purine

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Metal binding ability of hypermodified nucleosides of t-RNA. Potentiometric and spectroscopic studies on the metal complexes of N-[(9-β-D-ribofuranosylpurin-6-yl)carbamoyl] threonine. / Jezowska-Bojczuk, Malgorzata; Kozlowski, Henryk; Várnagy, K.; Sóvágó, I.; Swiatek, Jolanta; Adamiak, Ryszard W.

In: Journal of Inorganic Biochemistry, Vol. 40, No. 4, 1990, p. 357-363.

Research output: Contribution to journalArticle

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abstract = "Copper(II), nickel(II), zinc(II), manganese(II), and magnesium(II) complexes of t6A (N-[9-β-D-ribofuranosylpurin-6-yl)carbamoyl] threonine and t6Ade (N6(threoninocarbonyl)adenine) were studied by potentiometric and spectroscopic methods. It was found that t6Ade has three dissociable protons in the accessible pH range (N1 and N9 of purine and carboxylate), while only two pK values are characteristic of t6A. Magnesium(II) and manganese(II) do not interact effectively with these ligands, but copper(II) and nickel(II) ions form very stable complexes with the coordination of purine N1, deprotonated amide nitrogen, and carboxy late oxygen donors.",
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AU - Jezowska-Bojczuk, Malgorzata

AU - Kozlowski, Henryk

AU - Várnagy, K.

AU - Sóvágó, I.

AU - Swiatek, Jolanta

AU - Adamiak, Ryszard W.

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AB - Copper(II), nickel(II), zinc(II), manganese(II), and magnesium(II) complexes of t6A (N-[9-β-D-ribofuranosylpurin-6-yl)carbamoyl] threonine and t6Ade (N6(threoninocarbonyl)adenine) were studied by potentiometric and spectroscopic methods. It was found that t6Ade has three dissociable protons in the accessible pH range (N1 and N9 of purine and carboxylate), while only two pK values are characteristic of t6A. Magnesium(II) and manganese(II) do not interact effectively with these ligands, but copper(II) and nickel(II) ions form very stable complexes with the coordination of purine N1, deprotonated amide nitrogen, and carboxy late oxygen donors.

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