Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation

Krisztina Süle, K. Szentmihályi, Gergő Szabó, Dénes Kleiner, Imre Varga, Anna Egresi, Zoltán May, P. Nyírády, M. Mohai, A. Blázovics

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vitamin D3 supplementation has a beneficial effect on cancerous patients, although it can influence the redox- and metal homeostasis. The aim of our investigation was to demonstrate the effect of vitamin D3 consumption on the redox- and metal homeostasis in prostate cancer, because of the recommended daily dose increased from 200 IU to 2000 IU in recent years in Hungary. Forty-three volunteers were involved in the study. The grouping was applied according to the clinical routine laboratory parameters (vitamin D3) and the tumor markers (PSA, fPFA). Patients were divided into 5 groups: (A) patient control (N = 8), (B) patient control with vitamin D3 treatment (N = 9), (C) high-risk prostate cancer group (N = 6), (D) high-risk prostate cancer group with vitamin D3 treatment (N = 8) and (E) vitamin D3 treated cancerous group with androgen deprivation therapy (N = 11). The element concentrations were determined with ICP-OES. Among the redox parameters, free radical scavenging capacity and H-donating ability were determined with luminometry and spectrometry. Vitamin D3 treatment caused differences in the metal- and redox homeostasis in either patient control and cancerous groups. The concentration of Fe, Cr, and Pb significantly increased in the erythrocytes of prostate cancer patients. According to the higher scavenging capacity by vitamin D3 treatment, it seems that vitamin D3 helps to equilibrate the redox homeostasis that could affect the outcome of cancer positively. However, the tendency in the metal element status does not give a clear explanation of cancer's outcome, but the accumulation of Pb by vitamin D3 supplementation needs to be taken into more serious consideration in set terms of occupational diseases.

Original languageEnglish
Pages (from-to)558-565
Number of pages8
JournalBiomedicine and Pharmacotherapy
Volume105
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Cholecalciferol
Oxidation-Reduction
Prostatic Neoplasms
Homeostasis
Metals
Therapeutics
Occupational Diseases
Hungary
Tumor Biomarkers
Androgens
Free Radicals
Volunteers
Neoplasms
Spectrum Analysis
Erythrocytes
Control Groups

Keywords

  • ICP-OES
  • Micro-macro elements
  • prostate cancer
  • vitamin D

ASJC Scopus subject areas

  • Pharmacology

Cite this

Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation. / Süle, Krisztina; Szentmihályi, K.; Szabó, Gergő; Kleiner, Dénes; Varga, Imre; Egresi, Anna; May, Zoltán; Nyírády, P.; Mohai, M.; Blázovics, A.

In: Biomedicine and Pharmacotherapy, Vol. 105, 01.09.2018, p. 558-565.

Research output: Contribution to journalArticle

Süle, Krisztina ; Szentmihályi, K. ; Szabó, Gergő ; Kleiner, Dénes ; Varga, Imre ; Egresi, Anna ; May, Zoltán ; Nyírády, P. ; Mohai, M. ; Blázovics, A. / Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation. In: Biomedicine and Pharmacotherapy. 2018 ; Vol. 105. pp. 558-565.
@article{fbcf45c49ed641d1bcb24716f65a7317,
title = "Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation",
abstract = "Vitamin D3 supplementation has a beneficial effect on cancerous patients, although it can influence the redox- and metal homeostasis. The aim of our investigation was to demonstrate the effect of vitamin D3 consumption on the redox- and metal homeostasis in prostate cancer, because of the recommended daily dose increased from 200 IU to 2000 IU in recent years in Hungary. Forty-three volunteers were involved in the study. The grouping was applied according to the clinical routine laboratory parameters (vitamin D3) and the tumor markers (PSA, fPFA). Patients were divided into 5 groups: (A) patient control (N = 8), (B) patient control with vitamin D3 treatment (N = 9), (C) high-risk prostate cancer group (N = 6), (D) high-risk prostate cancer group with vitamin D3 treatment (N = 8) and (E) vitamin D3 treated cancerous group with androgen deprivation therapy (N = 11). The element concentrations were determined with ICP-OES. Among the redox parameters, free radical scavenging capacity and H-donating ability were determined with luminometry and spectrometry. Vitamin D3 treatment caused differences in the metal- and redox homeostasis in either patient control and cancerous groups. The concentration of Fe, Cr, and Pb significantly increased in the erythrocytes of prostate cancer patients. According to the higher scavenging capacity by vitamin D3 treatment, it seems that vitamin D3 helps to equilibrate the redox homeostasis that could affect the outcome of cancer positively. However, the tendency in the metal element status does not give a clear explanation of cancer's outcome, but the accumulation of Pb by vitamin D3 supplementation needs to be taken into more serious consideration in set terms of occupational diseases.",
keywords = "ICP-OES, Micro-macro elements, prostate cancer, vitamin D",
author = "Krisztina S{\"u}le and K. Szentmih{\'a}lyi and Gergő Szab{\'o} and D{\'e}nes Kleiner and Imre Varga and Anna Egresi and Zolt{\'a}n May and P. Ny{\'i}r{\'a}dy and M. Mohai and A. Bl{\'a}zovics",
year = "2018",
month = "9",
day = "1",
doi = "10.1016/j.biopha.2018.05.090",
language = "English",
volume = "105",
pages = "558--565",
journal = "Biomedicine and Pharmacotherapy",
issn = "0753-3322",
publisher = "Elsevier Masson",

}

TY - JOUR

T1 - Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation

AU - Süle, Krisztina

AU - Szentmihályi, K.

AU - Szabó, Gergő

AU - Kleiner, Dénes

AU - Varga, Imre

AU - Egresi, Anna

AU - May, Zoltán

AU - Nyírády, P.

AU - Mohai, M.

AU - Blázovics, A.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Vitamin D3 supplementation has a beneficial effect on cancerous patients, although it can influence the redox- and metal homeostasis. The aim of our investigation was to demonstrate the effect of vitamin D3 consumption on the redox- and metal homeostasis in prostate cancer, because of the recommended daily dose increased from 200 IU to 2000 IU in recent years in Hungary. Forty-three volunteers were involved in the study. The grouping was applied according to the clinical routine laboratory parameters (vitamin D3) and the tumor markers (PSA, fPFA). Patients were divided into 5 groups: (A) patient control (N = 8), (B) patient control with vitamin D3 treatment (N = 9), (C) high-risk prostate cancer group (N = 6), (D) high-risk prostate cancer group with vitamin D3 treatment (N = 8) and (E) vitamin D3 treated cancerous group with androgen deprivation therapy (N = 11). The element concentrations were determined with ICP-OES. Among the redox parameters, free radical scavenging capacity and H-donating ability were determined with luminometry and spectrometry. Vitamin D3 treatment caused differences in the metal- and redox homeostasis in either patient control and cancerous groups. The concentration of Fe, Cr, and Pb significantly increased in the erythrocytes of prostate cancer patients. According to the higher scavenging capacity by vitamin D3 treatment, it seems that vitamin D3 helps to equilibrate the redox homeostasis that could affect the outcome of cancer positively. However, the tendency in the metal element status does not give a clear explanation of cancer's outcome, but the accumulation of Pb by vitamin D3 supplementation needs to be taken into more serious consideration in set terms of occupational diseases.

AB - Vitamin D3 supplementation has a beneficial effect on cancerous patients, although it can influence the redox- and metal homeostasis. The aim of our investigation was to demonstrate the effect of vitamin D3 consumption on the redox- and metal homeostasis in prostate cancer, because of the recommended daily dose increased from 200 IU to 2000 IU in recent years in Hungary. Forty-three volunteers were involved in the study. The grouping was applied according to the clinical routine laboratory parameters (vitamin D3) and the tumor markers (PSA, fPFA). Patients were divided into 5 groups: (A) patient control (N = 8), (B) patient control with vitamin D3 treatment (N = 9), (C) high-risk prostate cancer group (N = 6), (D) high-risk prostate cancer group with vitamin D3 treatment (N = 8) and (E) vitamin D3 treated cancerous group with androgen deprivation therapy (N = 11). The element concentrations were determined with ICP-OES. Among the redox parameters, free radical scavenging capacity and H-donating ability were determined with luminometry and spectrometry. Vitamin D3 treatment caused differences in the metal- and redox homeostasis in either patient control and cancerous groups. The concentration of Fe, Cr, and Pb significantly increased in the erythrocytes of prostate cancer patients. According to the higher scavenging capacity by vitamin D3 treatment, it seems that vitamin D3 helps to equilibrate the redox homeostasis that could affect the outcome of cancer positively. However, the tendency in the metal element status does not give a clear explanation of cancer's outcome, but the accumulation of Pb by vitamin D3 supplementation needs to be taken into more serious consideration in set terms of occupational diseases.

KW - ICP-OES

KW - Micro-macro elements

KW - prostate cancer

KW - vitamin D

UR - http://www.scopus.com/inward/record.url?scp=85048117192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048117192&partnerID=8YFLogxK

U2 - 10.1016/j.biopha.2018.05.090

DO - 10.1016/j.biopha.2018.05.090

M3 - Article

C2 - 29886377

AN - SCOPUS:85048117192

VL - 105

SP - 558

EP - 565

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

SN - 0753-3322

ER -