Metachronous clear cell carcinoma of the tongue and kidney: A diagnostically challenging coincidence

Peter Novak, Farkas Sükösd, Sandor Hamar, Istvan Nemeth, L. Tiszlavicz, Istvan Szalay, Istvan Sonkodi, B. Iványi, K. Nagy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Clear cell carcinomas (CCCs) account for 1% of carcinomas of the salivary glands. A 63-year-old woman presented with a painless, nonulcerated, nodular mass on the right side of the tongue, without palpable neck nodes. After excision and cryotherapy of the mass, the histologic evaluation revealed CCC. At the age of 55, she had undergone radical nephrectomy for CCC of the kidney which extended into the renal vein (pT3aN0). Although she had remained metastasis-free during the follow-up, the clear cell morphology raised the possibility of late lingual metastasis of the renal CCC. A clinical search for metastases, and a series of immunostainings and analysis of the von Hippel-Lindau gene were therefore performed on paraffin-embedded blocks of both tumors: Primary metachronous CCC of the tongue was diagnosed. This case illustrates the diagnostic challenge posed by CCC of the tongue if there is a history of CCC of the kidney.

Original languageEnglish
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume114
Issue number4
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Tongue
Carcinoma
Kidney
Neoplasm Metastasis
Cryotherapy
Renal Veins
Salivary Glands
Nephrectomy
Renal Cell Carcinoma
Paraffin
Neck
Genes
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Dentistry (miscellaneous)

Cite this

Metachronous clear cell carcinoma of the tongue and kidney : A diagnostically challenging coincidence. / Novak, Peter; Sükösd, Farkas; Hamar, Sandor; Nemeth, Istvan; Tiszlavicz, L.; Szalay, Istvan; Sonkodi, Istvan; Iványi, B.; Nagy, K.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 114, No. 4, 10.2012.

Research output: Contribution to journalArticle

@article{32d77333e77c43809918f254886f3923,
title = "Metachronous clear cell carcinoma of the tongue and kidney: A diagnostically challenging coincidence",
abstract = "Clear cell carcinomas (CCCs) account for 1{\%} of carcinomas of the salivary glands. A 63-year-old woman presented with a painless, nonulcerated, nodular mass on the right side of the tongue, without palpable neck nodes. After excision and cryotherapy of the mass, the histologic evaluation revealed CCC. At the age of 55, she had undergone radical nephrectomy for CCC of the kidney which extended into the renal vein (pT3aN0). Although she had remained metastasis-free during the follow-up, the clear cell morphology raised the possibility of late lingual metastasis of the renal CCC. A clinical search for metastases, and a series of immunostainings and analysis of the von Hippel-Lindau gene were therefore performed on paraffin-embedded blocks of both tumors: Primary metachronous CCC of the tongue was diagnosed. This case illustrates the diagnostic challenge posed by CCC of the tongue if there is a history of CCC of the kidney.",
author = "Peter Novak and Farkas S{\"u}k{\"o}sd and Sandor Hamar and Istvan Nemeth and L. Tiszlavicz and Istvan Szalay and Istvan Sonkodi and B. Iv{\'a}nyi and K. Nagy",
year = "2012",
month = "10",
doi = "10.1016/j.oooo.2012.01.028",
language = "English",
volume = "114",
journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Metachronous clear cell carcinoma of the tongue and kidney

T2 - A diagnostically challenging coincidence

AU - Novak, Peter

AU - Sükösd, Farkas

AU - Hamar, Sandor

AU - Nemeth, Istvan

AU - Tiszlavicz, L.

AU - Szalay, Istvan

AU - Sonkodi, Istvan

AU - Iványi, B.

AU - Nagy, K.

PY - 2012/10

Y1 - 2012/10

N2 - Clear cell carcinomas (CCCs) account for 1% of carcinomas of the salivary glands. A 63-year-old woman presented with a painless, nonulcerated, nodular mass on the right side of the tongue, without palpable neck nodes. After excision and cryotherapy of the mass, the histologic evaluation revealed CCC. At the age of 55, she had undergone radical nephrectomy for CCC of the kidney which extended into the renal vein (pT3aN0). Although she had remained metastasis-free during the follow-up, the clear cell morphology raised the possibility of late lingual metastasis of the renal CCC. A clinical search for metastases, and a series of immunostainings and analysis of the von Hippel-Lindau gene were therefore performed on paraffin-embedded blocks of both tumors: Primary metachronous CCC of the tongue was diagnosed. This case illustrates the diagnostic challenge posed by CCC of the tongue if there is a history of CCC of the kidney.

AB - Clear cell carcinomas (CCCs) account for 1% of carcinomas of the salivary glands. A 63-year-old woman presented with a painless, nonulcerated, nodular mass on the right side of the tongue, without palpable neck nodes. After excision and cryotherapy of the mass, the histologic evaluation revealed CCC. At the age of 55, she had undergone radical nephrectomy for CCC of the kidney which extended into the renal vein (pT3aN0). Although she had remained metastasis-free during the follow-up, the clear cell morphology raised the possibility of late lingual metastasis of the renal CCC. A clinical search for metastases, and a series of immunostainings and analysis of the von Hippel-Lindau gene were therefore performed on paraffin-embedded blocks of both tumors: Primary metachronous CCC of the tongue was diagnosed. This case illustrates the diagnostic challenge posed by CCC of the tongue if there is a history of CCC of the kidney.

UR - http://www.scopus.com/inward/record.url?scp=84866351685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866351685&partnerID=8YFLogxK

U2 - 10.1016/j.oooo.2012.01.028

DO - 10.1016/j.oooo.2012.01.028

M3 - Article

C2 - 22986255

AN - SCOPUS:84866351685

VL - 114

JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

SN - 2212-4403

IS - 4

ER -