Metabotropic glutamate receptor in vasopressin, CRF and VIP hypothalamic neurones

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The excitatory amino acid glutamate, acting via ionotropic and metabotropic glutamate receptors, appears to play an important role in the control of neuroendocrine functions. The aim of the present investigations was to determine whether hypothalamic neurones which synthesize arginin- vasopressin (AVP), CRF and VIP express metabotropic glutamate receptor (mGluR). Double-label immunocytochemistry and the mirror technique were used. We found that AVP immunoreactive neurones of the paraventricular, supraoptic and suprachiasmatic nuclei contain mGluR1a, but the number of double-labelled neurones was different in the three cell groups. mGluR1a was present in a significant number of paraventricular CRF nerve cells, and in almost all VIP neurones of the SCHN. These results support the view that the excitatory transmitter glutamate may directly influence AVP, CRF and VIP neurones of the three hypothalamic cell groups.

Original languageEnglish
Pages (from-to)4029-4033
Number of pages5
JournalNeuroReport
Volume9
Issue number18
Publication statusPublished - Dec 21 1998

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Metabotropic Glutamate Receptors
Vasopressins
Neurons
Glutamic Acid
Ionotropic Glutamate Receptors
Supraoptic Nucleus
Excitatory Amino Acids
Suprachiasmatic Nucleus
Paraventricular Hypothalamic Nucleus
Immunohistochemistry

Keywords

  • Arginin-vasopressin
  • Co-localization
  • Corticotropin releasing factor
  • Metabotropic glutamate receptor
  • Paraventricular nucleus
  • Suprachiasmatic nucleus
  • Supraoptic nucleus
  • Vasoactive intestinal peptide

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Metabotropic glutamate receptor in vasopressin, CRF and VIP hypothalamic neurones. / Kocsis, K.; Kiss, J.; Görcs, T.; Halász, B.

In: NeuroReport, Vol. 9, No. 18, 21.12.1998, p. 4029-4033.

Research output: Contribution to journalArticle

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