Metabotropic glutamate receptor in GHRH and β-endorphin neurones of the hypothalamic arcuate nucleus

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Abstract

GROWTH hormone-releasing hormone (GHRH) and β-endorphin are mainly synthesized in neurones of the hypothalamic arcuate nucleus. Arcuate neurones also contain both ionotropic and metabotropic glutamate receptors. The aim of present study was to investigate whether glutamate receptors are present in GHRH and β-endorphin containing nerve cells of this hypothalamic area. Using double-label immunocytochemistry as well as the mirror technique, we found that almost all GHRH and β-endorphin immunoreactive arcuate neurones contain the metabotropic glutamate receptor 1a. The observations provide morphological evidence for the view that glutamate, which appears to be a major excitatory neurotransmitter in the hypothalamus, may directly stimulate GHRH and β-endorphin neurones of the medial hypothalamus.

Original languageEnglish
Pages (from-to)3703-3707
Number of pages5
JournalNeuroReport
Volume8
Issue number17
Publication statusPublished - 1997

Fingerprint

Endorphins
Arcuate Nucleus of Hypothalamus
Metabotropic Glutamate Receptors
Hormones
Neurons
Middle Hypothalamus
Ionotropic Glutamate Receptors
Glutamate Receptors
Hypothalamus
Neurotransmitter Agents
Glutamic Acid
Immunohistochemistry

Keywords

  • β-Endorphin
  • Arcuate nucleus
  • Co-localization
  • Growth hormone-releasing hormone
  • Metabotropic glutamate receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "GROWTH hormone-releasing hormone (GHRH) and β-endorphin are mainly synthesized in neurones of the hypothalamic arcuate nucleus. Arcuate neurones also contain both ionotropic and metabotropic glutamate receptors. The aim of present study was to investigate whether glutamate receptors are present in GHRH and β-endorphin containing nerve cells of this hypothalamic area. Using double-label immunocytochemistry as well as the mirror technique, we found that almost all GHRH and β-endorphin immunoreactive arcuate neurones contain the metabotropic glutamate receptor 1a. The observations provide morphological evidence for the view that glutamate, which appears to be a major excitatory neurotransmitter in the hypothalamus, may directly stimulate GHRH and β-endorphin neurones of the medial hypothalamus.",
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T1 - Metabotropic glutamate receptor in GHRH and β-endorphin neurones of the hypothalamic arcuate nucleus

AU - Kiss, J.

AU - Kocsis, K.

AU - Csáki, A.

AU - Görcs, T.

AU - Halász, B.

PY - 1997

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N2 - GROWTH hormone-releasing hormone (GHRH) and β-endorphin are mainly synthesized in neurones of the hypothalamic arcuate nucleus. Arcuate neurones also contain both ionotropic and metabotropic glutamate receptors. The aim of present study was to investigate whether glutamate receptors are present in GHRH and β-endorphin containing nerve cells of this hypothalamic area. Using double-label immunocytochemistry as well as the mirror technique, we found that almost all GHRH and β-endorphin immunoreactive arcuate neurones contain the metabotropic glutamate receptor 1a. The observations provide morphological evidence for the view that glutamate, which appears to be a major excitatory neurotransmitter in the hypothalamus, may directly stimulate GHRH and β-endorphin neurones of the medial hypothalamus.

AB - GROWTH hormone-releasing hormone (GHRH) and β-endorphin are mainly synthesized in neurones of the hypothalamic arcuate nucleus. Arcuate neurones also contain both ionotropic and metabotropic glutamate receptors. The aim of present study was to investigate whether glutamate receptors are present in GHRH and β-endorphin containing nerve cells of this hypothalamic area. Using double-label immunocytochemistry as well as the mirror technique, we found that almost all GHRH and β-endorphin immunoreactive arcuate neurones contain the metabotropic glutamate receptor 1a. The observations provide morphological evidence for the view that glutamate, which appears to be a major excitatory neurotransmitter in the hypothalamus, may directly stimulate GHRH and β-endorphin neurones of the medial hypothalamus.

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KW - Co-localization

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