Metabolites of Aliphatic Alcohols Detected in Alcoholic Beverages Inhibit Phagocytosis

Ervin M. Árnyas, László Pál, Gergő Baranyi, Orsolya Bujdosó, Gábor Rácz, R. Ádány, Martin McKee, Sándor Szűcs

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

AIMS: The aim of our study was to measure granulocyte and monocyte phagocytosis following treatment of cells with some metabolites of aliphatic alcohols alone and in combination with acetaldehyde.

METHODS: The cells were separated from human peripheral blood prior to determination of phagocytosis of opsonized zymosan particles by granulocytes and monocytes treated individually with metabolites of aliphatic alcohols including formaldehyde, 1-propanal, acetone, 1-butanal, and 2-butanone and in combination with acetaldehyde.

RESULTS: The findings revealed that metabolites of aliphatic alcohols inhibited phagocytosis by granulocytes and monocytes in a concentration-dependent manner and when combined with acetaldehyde, they caused a further decrease in phagocytic activity.

CONCLUSION: Due to their additive effects, it is possible that, in combination with acetaldehyde, metabolites of aliphatic alcohols may inhibit phagocytosis at physiologically realistic concentrations in episodic heavy drinkers, thereby contributing to their increased susceptibility to infectious diseases.

Original languageEnglish
Pages (from-to)388-394
Number of pages7
JournalAlcohol and alcoholism (Oxford, Oxfordshire)
Volume51
Issue number4
DOIs
Publication statusPublished - Jul 1 2016

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Medicine(all)
  • Toxicology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Metabolites of Aliphatic Alcohols Detected in Alcoholic Beverages Inhibit Phagocytosis'. Together they form a unique fingerprint.

  • Cite this