Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development

P. Mátyus, Christina L L Chai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Multitargeting is a valuable concept in drug design for the development of effective drugs for the treatment of multifactorial diseases. This concept has most frequently been realized by incorporating two or more pharmacophores into a single hybrid molecule. Many such hybrids, due to the increased molecular size, exhibit unfavorable physicochemical properties leading to adverse effects and/or an inappropriate ADME (absorption, distribution, metabolism, and excretion) profile. To avoid this limitation and achieve additional therapeutic benefits, here we describe a novel multitargeting strategy based on the synergistic effects of a parent drug and its active metabolite(s). The concept of metabolism-activated multitargeting (MAMUT) is illustrated using a number of examples.

Original languageEnglish
Pages (from-to)1197-1198
Number of pages2
JournalChemMedChem
DOIs
Publication statusPublished - Jun 20 2016

Fingerprint

Drug Design
Metabolism
Pharmaceutical Preparations
Metabolites
Molecules
Therapeutics

Keywords

  • active metabolites
  • designed multiple ligands (DMLs)
  • drug design
  • metabolism-activated multitargeting (MAMUT)
  • synergism

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

Cite this

Metabolism-Activated Multitargeting (MAMUT) : An Innovative Multitargeting Approach to Drug Design and Development. / Mátyus, P.; Chai, Christina L L.

In: ChemMedChem, 20.06.2016, p. 1197-1198.

Research output: Contribution to journalArticle

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