Metabolic transformation of deprenyl enantiomers in rats

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The optical isomers of deprenyl have different pharmacological activities and potency. Selegiline, an (-)-isomer, is the more potent monoamine oxidase B enzyme inhibitor, and this substance is used in the therapy of Parkinson's disease. The neuroprotective and neuronal rescue effects of deprenyl, as well as the psychostimulant action of its metabolites, methamphetamine and amphetamine are also different for the enantiomers. In this study the biotransformation of deprenyl enantiomers was compared. Stereoselective dealkylation of both optical isomers was found as major metabolic alteration. The difference in the ratio of the formed metabolites suggests the existence of preferred metabolic pathways for the enantiomers.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalNeurobiology
Volume7
Issue number2
Publication statusPublished - 1999

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Selegiline
Dealkylation
Methamphetamine
Monoamine Oxidase
Enzyme Inhibitors
Amphetamine
Biotransformation
Metabolic Networks and Pathways
Parkinson Disease
Pharmacology

Keywords

  • Capillary electrophoresis
  • Deprenyl
  • Enantiomer
  • Metabolism

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Metabolic transformation of deprenyl enantiomers in rats. / Szökő, É.; Kalász, H.; Magyar, K.

In: Neurobiology, Vol. 7, No. 2, 1999, p. 247-254.

Research output: Contribution to journalArticle

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