Metabolic roles of poly(ADP-ribose) polymerases

András Vida, Judit Márton, Edit Mikó, Péter Bai

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Poly(ADP-ribosyl)ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic transcription factors (e.g. SIRT1, nuclear receptors, SREBPs) and certain cellular energy sensors. PARP over-activation can cause damage to mitochondrial terminal oxidation, while the inhibition of PARP-1 or PARP-2 can induce mitochondrial oxidation by enhancing the mitotropic tone of gene transcription and signal transduction. These PARP-mediated processes impact on higher order metabolic regulation that modulates lipid metabolism, circadian oscillations and insulin secretion and signaling. PARP-1, PARP-2 and PARP-7 are related to metabolic diseases such as diabetes, alcoholic and non-alcoholic fatty liver disease (AFLD, NAFLD), or on a broader perspective to Warburg metabolism in cancer or the metabolic diseases accompanying aging.

Original languageEnglish
Pages (from-to)135-143
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume63
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • ARTD
  • Diabetes
  • Metabolism
  • Mitochondria
  • Obesity
  • PARP

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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