Metabolic responses to severe perinatal asphyxia in term newborn infants with particular reference to the changes in plasma free amino acids

K. Schultz, G. Soltész, J. Mestyán

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Blood glucose, blood lactate, plasma FFA, plasma α-amino nitrogen and 17 individual amino acids were determined on admission, and at 24 and 48 h after admission in severely asphyxiated term newborn infants. The blood glucose value was widely scattered and the plasma FFA level was low on admission. The total free plasma amino acid content correlated closely with the severity of asphyxia-induced lactic acidosis. Among the 17 amino acids determined, 11 turned out to be significantly increased. The increase of plasma free amino acids might be toxic for the central nervous system, therefore parenteral feeding of asphyxiated neonates with amino acid mixtures can be dangerous.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalNeonatology
Volume39
Issue number3-4
DOIs
Publication statusPublished - Jan 1 1981

Keywords

  • Free amino acids
  • Newborn infant Plasma metabolites
  • Perinatal asphyxia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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