Metabolic gene polymorphism frequencies in control populations

S. Garte, L. Gaspari, A. K. Alexandrie, C. Ambrosone, H. Autrup, J. L. Autrup, H. Baranova, L. Bathum, S. Benhamou, P. Boffetta, C. Bouchardy, K. Breskvar, J. Brockmoller, I. Cascorbi, M. L. Clapper, C. Coutelle, A. Daly, M. Dell'Omo, V. Dolzan, C. M. Dresler & 46 others A. Fryer, A. Haugen, D. W. Hein, A. Hildesheim, A. Hirvonen, L. L. Hsieh, M. Ingelman-Sundberg, I. Kalina, D. Kang, M. Kihara, C. Kiyohara, P. Kremers, P. Lazarus, L. Le Marchand, M. C. Lechner, E. M M Van Lieshout, S. London, J. J. Manni, C. M. Maugard, S. Morita, V. Nazar-Stewart, K. Noda, Y. Oda, F. F. Parl, R. Pastorelli, I. Persson, W. H M Peters, A. Rannug, T. Rebbeck, A. Risch, L. Roelandt, M. Romkes, D. Ryberg, J. Salagovic, B. Schoket, J. Seidegard, P. G. Shields, E. Sim, D. Sinnet, R. C. Strange, I. Stücker, H. Sugimura, J. To-Figueras, P. Vineis, M. C. Yu, E. Taioli

Research output: Contribution to journalArticle

725 Citations (Scopus)

Abstract

Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

Original languageEnglish
Pages (from-to)1239-1248
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume10
Issue number12
Publication statusPublished - 2001

Fingerprint

Gene Frequency
Environmental Carcinogens
Cytochrome P-450 CYP2E1
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP1A1
Population Control
Linkage Disequilibrium
Genetic Predisposition to Disease
African Americans
Population
Alleles
Genotype
Databases
Genes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Garte, S., Gaspari, L., Alexandrie, A. K., Ambrosone, C., Autrup, H., Autrup, J. L., ... Taioli, E. (2001). Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology Biomarkers and Prevention, 10(12), 1239-1248.

Metabolic gene polymorphism frequencies in control populations. / Garte, S.; Gaspari, L.; Alexandrie, A. K.; Ambrosone, C.; Autrup, H.; Autrup, J. L.; Baranova, H.; Bathum, L.; Benhamou, S.; Boffetta, P.; Bouchardy, C.; Breskvar, K.; Brockmoller, J.; Cascorbi, I.; Clapper, M. L.; Coutelle, C.; Daly, A.; Dell'Omo, M.; Dolzan, V.; Dresler, C. M.; Fryer, A.; Haugen, A.; Hein, D. W.; Hildesheim, A.; Hirvonen, A.; Hsieh, L. L.; Ingelman-Sundberg, M.; Kalina, I.; Kang, D.; Kihara, M.; Kiyohara, C.; Kremers, P.; Lazarus, P.; Le Marchand, L.; Lechner, M. C.; Van Lieshout, E. M M; London, S.; Manni, J. J.; Maugard, C. M.; Morita, S.; Nazar-Stewart, V.; Noda, K.; Oda, Y.; Parl, F. F.; Pastorelli, R.; Persson, I.; Peters, W. H M; Rannug, A.; Rebbeck, T.; Risch, A.; Roelandt, L.; Romkes, M.; Ryberg, D.; Salagovic, J.; Schoket, B.; Seidegard, J.; Shields, P. G.; Sim, E.; Sinnet, D.; Strange, R. C.; Stücker, I.; Sugimura, H.; To-Figueras, J.; Vineis, P.; Yu, M. C.; Taioli, E.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 10, No. 12, 2001, p. 1239-1248.

Research output: Contribution to journalArticle

Garte, S, Gaspari, L, Alexandrie, AK, Ambrosone, C, Autrup, H, Autrup, JL, Baranova, H, Bathum, L, Benhamou, S, Boffetta, P, Bouchardy, C, Breskvar, K, Brockmoller, J, Cascorbi, I, Clapper, ML, Coutelle, C, Daly, A, Dell'Omo, M, Dolzan, V, Dresler, CM, Fryer, A, Haugen, A, Hein, DW, Hildesheim, A, Hirvonen, A, Hsieh, LL, Ingelman-Sundberg, M, Kalina, I, Kang, D, Kihara, M, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, MC, Van Lieshout, EMM, London, S, Manni, JJ, Maugard, CM, Morita, S, Nazar-Stewart, V, Noda, K, Oda, Y, Parl, FF, Pastorelli, R, Persson, I, Peters, WHM, Rannug, A, Rebbeck, T, Risch, A, Roelandt, L, Romkes, M, Ryberg, D, Salagovic, J, Schoket, B, Seidegard, J, Shields, PG, Sim, E, Sinnet, D, Strange, RC, Stücker, I, Sugimura, H, To-Figueras, J, Vineis, P, Yu, MC & Taioli, E 2001, 'Metabolic gene polymorphism frequencies in control populations', Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 12, pp. 1239-1248.
Garte S, Gaspari L, Alexandrie AK, Ambrosone C, Autrup H, Autrup JL et al. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiology Biomarkers and Prevention. 2001;10(12):1239-1248.
Garte, S. ; Gaspari, L. ; Alexandrie, A. K. ; Ambrosone, C. ; Autrup, H. ; Autrup, J. L. ; Baranova, H. ; Bathum, L. ; Benhamou, S. ; Boffetta, P. ; Bouchardy, C. ; Breskvar, K. ; Brockmoller, J. ; Cascorbi, I. ; Clapper, M. L. ; Coutelle, C. ; Daly, A. ; Dell'Omo, M. ; Dolzan, V. ; Dresler, C. M. ; Fryer, A. ; Haugen, A. ; Hein, D. W. ; Hildesheim, A. ; Hirvonen, A. ; Hsieh, L. L. ; Ingelman-Sundberg, M. ; Kalina, I. ; Kang, D. ; Kihara, M. ; Kiyohara, C. ; Kremers, P. ; Lazarus, P. ; Le Marchand, L. ; Lechner, M. C. ; Van Lieshout, E. M M ; London, S. ; Manni, J. J. ; Maugard, C. M. ; Morita, S. ; Nazar-Stewart, V. ; Noda, K. ; Oda, Y. ; Parl, F. F. ; Pastorelli, R. ; Persson, I. ; Peters, W. H M ; Rannug, A. ; Rebbeck, T. ; Risch, A. ; Roelandt, L. ; Romkes, M. ; Ryberg, D. ; Salagovic, J. ; Schoket, B. ; Seidegard, J. ; Shields, P. G. ; Sim, E. ; Sinnet, D. ; Strange, R. C. ; Stücker, I. ; Sugimura, H. ; To-Figueras, J. ; Vineis, P. ; Yu, M. C. ; Taioli, E. / Metabolic gene polymorphism frequencies in control populations. In: Cancer Epidemiology Biomarkers and Prevention. 2001 ; Vol. 10, No. 12. pp. 1239-1248.
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title = "Metabolic gene polymorphism frequencies in control populations",
abstract = "Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.",
author = "S. Garte and L. Gaspari and Alexandrie, {A. K.} and C. Ambrosone and H. Autrup and Autrup, {J. L.} and H. Baranova and L. Bathum and S. Benhamou and P. Boffetta and C. Bouchardy and K. Breskvar and J. Brockmoller and I. Cascorbi and Clapper, {M. L.} and C. Coutelle and A. Daly and M. Dell'Omo and V. Dolzan and Dresler, {C. M.} and A. Fryer and A. Haugen and Hein, {D. W.} and A. Hildesheim and A. Hirvonen and Hsieh, {L. L.} and M. Ingelman-Sundberg and I. Kalina and D. Kang and M. Kihara and C. Kiyohara and P. Kremers and P. Lazarus and {Le Marchand}, L. and Lechner, {M. C.} and {Van Lieshout}, {E. M M} and S. London and Manni, {J. J.} and Maugard, {C. M.} and S. Morita and V. Nazar-Stewart and K. Noda and Y. Oda and Parl, {F. F.} and R. Pastorelli and I. Persson and Peters, {W. H M} and A. Rannug and T. Rebbeck and A. Risch and L. Roelandt and M. Romkes and D. Ryberg and J. Salagovic and B. Schoket and J. Seidegard and Shields, {P. G.} and E. Sim and D. Sinnet and Strange, {R. C.} and I. St{\"u}cker and H. Sugimura and J. To-Figueras and P. Vineis and Yu, {M. C.} and E. Taioli",
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TY - JOUR

T1 - Metabolic gene polymorphism frequencies in control populations

AU - Garte, S.

AU - Gaspari, L.

AU - Alexandrie, A. K.

AU - Ambrosone, C.

AU - Autrup, H.

AU - Autrup, J. L.

AU - Baranova, H.

AU - Bathum, L.

AU - Benhamou, S.

AU - Boffetta, P.

AU - Bouchardy, C.

AU - Breskvar, K.

AU - Brockmoller, J.

AU - Cascorbi, I.

AU - Clapper, M. L.

AU - Coutelle, C.

AU - Daly, A.

AU - Dell'Omo, M.

AU - Dolzan, V.

AU - Dresler, C. M.

AU - Fryer, A.

AU - Haugen, A.

AU - Hein, D. W.

AU - Hildesheim, A.

AU - Hirvonen, A.

AU - Hsieh, L. L.

AU - Ingelman-Sundberg, M.

AU - Kalina, I.

AU - Kang, D.

AU - Kihara, M.

AU - Kiyohara, C.

AU - Kremers, P.

AU - Lazarus, P.

AU - Le Marchand, L.

AU - Lechner, M. C.

AU - Van Lieshout, E. M M

AU - London, S.

AU - Manni, J. J.

AU - Maugard, C. M.

AU - Morita, S.

AU - Nazar-Stewart, V.

AU - Noda, K.

AU - Oda, Y.

AU - Parl, F. F.

AU - Pastorelli, R.

AU - Persson, I.

AU - Peters, W. H M

AU - Rannug, A.

AU - Rebbeck, T.

AU - Risch, A.

AU - Roelandt, L.

AU - Romkes, M.

AU - Ryberg, D.

AU - Salagovic, J.

AU - Schoket, B.

AU - Seidegard, J.

AU - Shields, P. G.

AU - Sim, E.

AU - Sinnet, D.

AU - Strange, R. C.

AU - Stücker, I.

AU - Sugimura, H.

AU - To-Figueras, J.

AU - Vineis, P.

AU - Yu, M. C.

AU - Taioli, E.

PY - 2001

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AB - Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

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