Metabolic control, glycosylated haemoglobin and high density lipoprotein cholesterol in diabetic children

L. Klujber, D. Molnár, M. Kardos, V. Jászai, G. Soltész, J. Mestyán

Research output: Contribution to journalArticle

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Abstract

The present study on 28 diabetic and 38 non-diabetic children was conducted to extend information on the usefulness of HbAIa-c measurement in assessing the effectiveness of metabolic control, and to investigate to what extent HbAIa-c and blood glucose reflect changes in plasma cholesterol, especially high density lipoprotein cholesterol. Since the activities of serum lysosomal hydrolases are reported to be increased in diabetic patients, it was of interest to examine the changes in serum N-acetyl-β-D-glucosaminidase in relation to HbAIa-c. Both fasting blood glucose and daily urinary glucose excretion were found to be positively related to HbAIa-c. The poorly controlled diabetic children exhibited the highest percentage of glycosylated haemoglobins. The total cholesterol and HDL-cholesterol content-as well as the activity of N-acetyl-β-D-glucosaminidase in the plasma-were also found to be directly related to the proportion of HbAIa-c. The measurement of glycosylated haemoglobins thus appears to be an important and useful aid in determining the effectiveness of long term control in juvenile diabetes. The interesting findings that HDL-cholesterol was significantly higher in diabetic children than in agematched controls, and that it was positively related to the fasting blood glucose and glycosylated haemoglobins, supports recent suggestions that there is an essential difference in plasma HDL-cholesterol between juvenile and adult onst diabetes. This fraction of plasma cholesterol, which represents a negative risk factor of coronary atherosclerosis, was significantly higher in the diabetic children than in patients with adult-onset diabetes.

Original languageEnglish
Pages (from-to)289-297
Number of pages9
JournalEuropean Journal of Pediatrics
Volume132
Issue number4
DOIs
Publication statusPublished - Dec 1979

Fingerprint

Glycosylated Hemoglobin A
HDL Cholesterol
Blood Glucose
Hexosaminidases
Cholesterol
Fasting
Hydrolases
Serum
Coronary Artery Disease
Glucose

Keywords

  • Diabetic control
  • Glycosylated haemoglobins
  • HDL-cholesterol
  • Juvenile diseases
  • Lysozymed hydrolyses

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Metabolic control, glycosylated haemoglobin and high density lipoprotein cholesterol in diabetic children. / Klujber, L.; Molnár, D.; Kardos, M.; Jászai, V.; Soltész, G.; Mestyán, J.

In: European Journal of Pediatrics, Vol. 132, No. 4, 12.1979, p. 289-297.

Research output: Contribution to journalArticle

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