Metabolic changes of patients with acute necrotizing pancreatitis

E. Roth, G. Zoch, W. Mauritz, J. Karner, J. Funovics, P. Sporn, A. Fritsch

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We carried out metabolic investigations of 26 patients with severe forms of acute pancreatitis which were evaluated by an organ score. We formed six groups from this data: survivors and those who died in the first week, the second week, and after a further two weeks of illness. The amino acid patterns in plasma and muscles deviated considerably from normal at all times in both the surviving and the dead patients. In particular, changes in the concentrations of branched-chain amino acids and glutamine in the muscle tissue have a prognostic value. In the range two to four (normal range: above 20), the factor (glutamine)/(VAL + LEU + ILE) characterizes a prefinal condition in non-survivors. This factor increased in patients recovering from the illness from 6 to values over 20. Non-survivors (NS) had higher plasma levels of glucose and glucagon compared to surviving patients. Plasma glucagon concentrations in NS reached levels up to 4,000 pg/mL at admission, which declined gradually to the normal range during the course of the illness.

Original languageEnglish
Pages (from-to)172-179
Number of pages8
JournalInfusionstherapie und Klinische Ernahrung - Forschung und Praxis
Volume13
Issue number4
DOIs
Publication statusPublished - Jan 1 1986

    Fingerprint

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this