Metabolic and hormonal response to endotoxin fever in fed and starved one-week rabbits

D. Molnar, R. D.G. Milner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The metabolic and hormonal effect of Escherichia coli endotoxin injected intra- peritoneally was studied in fed and starved rabbits aged 6-9 days. Fed rabbits responded to endotoxin with fever, starved animals became hypothermic. Endotoxin caused a transient rise in blood glucose in both groups which was associated with a rise in plasma insulin concentration. Blood glycerol levels fell only in starved rabbits, and hydroxybutyrate concentration in both groups following endotoxin treatment. No change in blood pyruvate, lactate, alanine, or acetoacetate level was observed in either group.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalNeonatology
Volume44
Issue number5
DOIs
Publication statusPublished - Jan 1 1983

    Fingerprint

Keywords

  • Endotoxin
  • Fever
  • Hypothermia
  • Insulin
  • Metabolites
  • Rabbit

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

Cite this