Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting

James J. Dinicolantonio, Craig J. Beavers, Arthur R. Menezes, Carl J. Lavie, James H. O'Keefe, Pascal Meier, András Vorobcsuk, Dániel Aradi, András Komócsi, Saurav Chatterjee, Fabrizio D'Ascenzo, Mauro Gasparini, Jasper Brugts, Giuseppe Biondi-Zoccai

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28 Citations (Scopus)

Abstract

A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalAmerican Journal of Cardiology
Volume113
Issue number3
DOIs
Publication statusPublished - Feb 1 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Dinicolantonio, J. J., Beavers, C. J., Menezes, A. R., Lavie, C. J., O'Keefe, J. H., Meier, P., Vorobcsuk, A., Aradi, D., Komócsi, A., Chatterjee, S., D'Ascenzo, F., Gasparini, M., Brugts, J., & Biondi-Zoccai, G. (2014). Meta-analysis comparing carvedilol versus metoprolol for the prevention of postoperative atrial fibrillation following coronary artery bypass grafting. American Journal of Cardiology, 113(3), 565-569. https://doi.org/10.1016/j.amjcard.2013.10.020