Mesoporous silica core–shell composite functionalized with polyelectrolytes for drug delivery

N. Varga, M. Benkő, D. Sebők, G. Bohus, L. Janovák, I. Dékány

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Porous, spherical (d ≈ 400 nm) polyelectrolytes-coated silica particles (SiPs) with high surface area (1254 m 2 /g) have been synthesized for controlled release of ibuprofen (IBU) in aqueous dispersion. The zeta potential of the SiPs was negative (−77 mV) at pH 5.5, so the shells, as a positively charged polyethylenimine (PEI) and a negatively charged poly(sodium-4-styrenesulfonate) (PSS) bind through electrostatic interactions. The adsorbed amount of IBU is 1666 mg/g and 1618 mg/g SiPs based on adsorption method in aqueous media and thermogravimetric (TG) measurement, respectively. The SiPs was characterized by using low temperature N 2 adsorption/desorption method. The well-ordered structure of SiPs and the fractal dimensions of the core–shell composites were determined by small angle X-ray scattering (SAXS) measurement. Finally the release properties of the IBU have been investigated; kinetic models were used to describe the release mechanism. The results of this study highlighted that the SiPs and the core–shell particles are well applicable as dissolution-enhancing systems for encapsulation of poorly soluble drugs.

Original languageEnglish
Pages (from-to)134-141
Number of pages8
JournalMicroporous and Mesoporous Materials
Volume213
DOIs
Publication statusPublished - Sep 1 2015

    Fingerprint

Keywords

  • Controlled release
  • Core–shell composites
  • Ibuprofen
  • Mesoporous silica
  • SAXS

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials

Cite this