A mesenchymalis ossejtek és az immunrendszer - Immunszuppresszió gyógyszerek nélkül?

Translated title of the contribution: Mesenchymal stem cells and the immune system - Immunosuppression without drugs

Judit Kiss, S. Veronika Urbán, Valéria Dudics, Virág Vas, F. Uher

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSC) - isolated from various tissues in humans and other species - are one of the most promising adult stem cell types due to their availability and the relatively simple requirements for in vitro expansion. They have the capacity to differentiate into several tissues, including bone, cartilage, tendon, muscle and adipose, and produce growth factors and cytokines that promote hematopoietic cell expansion and differentiation. In vivo, MSCs are able to repair damaged tissue from kidney, heart, liver, pancreas and gastrointestinal tract. Furthermore, they also have anti-proliferative, immunomodulatory and anti-inflammatory effects, but evoke only little immune reactivity. Although the mechanism underlying the immunosuppressive effects of MSCs has not been clearly defined, their immunosuppressive properties have already been exploited in the clinical setting. Therefore, in the future, MSCs might have implications for treatment of allograft rejection, graft-versus-host disease, rheumatoid arthritis, autoimmune inflammatory bowel disease and other disorders in which immunomodulation and tissue repair are required. The aim of this review is to critically analyze the field of MSC biology, particularly with respect to their immunomodulatory properties and potential clinical use in the future.

Original languageHungarian
Pages (from-to)339-346
Number of pages8
JournalOrvosi Hetilap
Volume149
Issue number8
DOIs
Publication statusPublished - Feb 24 2008

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Mesenchymal Stromal Cells
Immunosuppression
Immune System
Immunosuppressive Agents
Pharmaceutical Preparations
Adult Stem Cells
Immunomodulation
Graft vs Host Disease
Inflammatory Bowel Diseases
Tendons
Cartilage
Allografts
Cell Biology
Gastrointestinal Tract
Cell Differentiation
Pancreas
Rheumatoid Arthritis
Intercellular Signaling Peptides and Proteins
Anti-Inflammatory Agents
Cytokines

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A mesenchymalis ossejtek és az immunrendszer - Immunszuppresszió gyógyszerek nélkül? / Kiss, Judit; Urbán, S. Veronika; Dudics, Valéria; Vas, Virág; Uher, F.

In: Orvosi Hetilap, Vol. 149, No. 8, 24.02.2008, p. 339-346.

Research output: Contribution to journalArticle

Kiss, Judit ; Urbán, S. Veronika ; Dudics, Valéria ; Vas, Virág ; Uher, F. / A mesenchymalis ossejtek és az immunrendszer - Immunszuppresszió gyógyszerek nélkül?. In: Orvosi Hetilap. 2008 ; Vol. 149, No. 8. pp. 339-346.
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