Merit of estimations from DSC measurements for the efficiency of optical resolutions

J. Madarász, D. Kozma, G. Pokol, M. Ács, E. Fogassy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Chiral drugs are generally resolved through formation of diastereoisomeric salts of different solubility. When the diastereoisomer salts from a eutectic in the solid phase, a good estimate can be made for the efficiency of the resolution (S), through a calculation based on the eutectic composition (x eu). The eutectic composition can be computed from thermal data of a differential scanning calorimetric (DSC) measurement of the diastereoisomeric salts [1]. In this work we investigated the influence of uncertainties of thermal data on the estimation of the efficiency of resolution (S), spreading throughout the calculations involved. Performance of our error-estimating method is demonstrated on 6 diastereoisomer salt pairs. The obtained deviations are close to the deviations of resolution experiments. Thus, it can be concluded that the DSC measurements are useful means in predicting the efficiency of resolutions.

Original languageEnglish
Pages (from-to)877-894
Number of pages18
JournalJournal of Thermal Analysis
Volume42
Issue number5
DOIs
Publication statusPublished - Nov 1994

Fingerprint

Salts
eutectics
Eutectics
salts
Scanning
scanning
deviation
Chemical analysis
solid phases
drugs
estimating
solubility
Solubility
estimates
Pharmaceutical Preparations
Experiments
Hot Temperature

Keywords

  • DSC
  • efficiency of optical resolution
  • error estimation
  • eutectic phase diagram

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Engineering(all)

Cite this

Merit of estimations from DSC measurements for the efficiency of optical resolutions. / Madarász, J.; Kozma, D.; Pokol, G.; Ács, M.; Fogassy, E.

In: Journal of Thermal Analysis, Vol. 42, No. 5, 11.1994, p. 877-894.

Research output: Contribution to journalArticle

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