Meningioma recurrence

T. Hortobágyi, János Bencze, Gréta Varkoly, Mahan C. Kouhsari, A. Klekner

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Meningioma accounts for more than 30% of all intracranial tumours. It affects mainly the elderly above the age of 60, at a female:male ratio of 3:2. The prognosis is variable: it is usually favourable with no progression in tumour grade and no recurrence in WHO grade 1 tumours. However, a minority of tumours represent atypical (grade 2) or anaplastic (grade 3) meningiomas; this heterogeneity is also reflected in histopathological appearances. Irrespective of the grade, the size of the tumour and the localisation may have severe, sometimes lethal consequences. Following neurosurgical interventions to remove the tumour, recurrence and progression in WHO grade may occur. Our knowledge on predisposing histomorphological and molecular factors of recurrence is rather limited. These can be classified as I) demographic II) environmental, III) genetic and epigenetic IV) imaging, V) neuropathological, and VI) neurosurgical. In view of the complex background of tumour recurrence, the recognition of often subtle signs of increased risk of recurrence requires close collaboration of experts from several medical specialties. This multidisciplinary approach results in better therapy and fewer complications related to tumour recurrence.

Original languageEnglish
Pages (from-to)168-173
Number of pages6
JournalOpen Medicine (Poland)
Volume11
Issue number1
DOIs
Publication statusPublished - Jun 1 2016

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Meningioma
Recurrence
Neoplasms
Epigenomics
Medicine
Demography

Keywords

  • Genetics
  • Immunohistochemistry
  • Meningioma
  • Molecular biology
  • Neuropathology
  • Pathology
  • Prognostic factors
  • Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Meningioma recurrence. / Hortobágyi, T.; Bencze, János; Varkoly, Gréta; Kouhsari, Mahan C.; Klekner, A.

In: Open Medicine (Poland), Vol. 11, No. 1, 01.06.2016, p. 168-173.

Research output: Contribution to journalReview article

Hortobágyi, T, Bencze, J, Varkoly, G, Kouhsari, MC & Klekner, A 2016, 'Meningioma recurrence', Open Medicine (Poland), vol. 11, no. 1, pp. 168-173. https://doi.org/10.1515/med-2016-0032
Hortobágyi, T. ; Bencze, János ; Varkoly, Gréta ; Kouhsari, Mahan C. ; Klekner, A. / Meningioma recurrence. In: Open Medicine (Poland). 2016 ; Vol. 11, No. 1. pp. 168-173.
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