Menin and its interacting proteins: elucidation of menin function

Katalin Balogh, K. Rácz, A. Patócs, L. Hunyady

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The multiple endocrine neoplasia type 1 (MEN1) gene is a tumor suppressor gene encoding a 610 amino acid nuclear protein, menin. Although mutations of the MEN1 gene are responsible for MEN 1 syndrome, the intracellular functions of menin have not been fully elucidated. Recent data suggest that interactions between menin and menin-interacting proteins have a role in physiological regulation of cell growth, control of the cell cycle and genome stability, and are potentially important in bone development and multipotent mesenchymal stem cell differentiation. Loss of these interactions might also contribute to the development of MEN 1 syndrome.

Original languageEnglish
Pages (from-to)357-364
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume17
Issue number9
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Multiple Endocrine Neoplasia Type 1
Proteins
Multipotent Stem Cells
Genomic Instability
Bone Development
Nuclear Proteins
Cell Cycle Checkpoints
Tumor Suppressor Genes
Mesenchymal Stromal Cells
Genes
Cell Differentiation
Amino Acids
Mutation
Growth

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Menin and its interacting proteins : elucidation of menin function. / Balogh, Katalin; Rácz, K.; Patócs, A.; Hunyady, L.

In: Trends in Endocrinology and Metabolism, Vol. 17, No. 9, 11.2006, p. 357-364.

Research output: Contribution to journalArticle

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